Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1959 Aug;38(8):1328–1333. doi: 10.1172/JCI103907

EVALUATION OF NICOTINIC ACID AS AN HYPOCHOLESTEREMIC AND ANTI-ATHEROGENIC SUBSTANCE *

Meyer Friedman 1, Sanford O Byers 1, Warren Hayashi 1, Clarence Omoto 1, Betty Tsai 1
PMCID: PMC442086  PMID: 13673088

Full text

PDF
1328

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALTSCHUL R., HOFFER A., STEPHEN J. D. Influence of nicotinic acid on serum cholesterol in man. Arch Biochem Biophys. 1955 Feb;54(2):558–559. doi: 10.1016/0003-9861(55)90070-9. [DOI] [PubMed] [Google Scholar]
  2. BLOOM B., CHAIKOFF I. L., REINHARDT W. O., ENTENMAN C., DAUBEN W. G. The quantitative significance of the lymphatic pathway in transport of absorbed fatty acids. J Biol Chem. 1950 May;184(1):1–8. [PubMed] [Google Scholar]
  3. BORGSTROM B., LINDHE B. A., WLODAWER P. Absorption and distribution of cholesterol-4-C14 in the rat. Proc Soc Exp Biol Med. 1958 Nov;99(2):365–368. doi: 10.3181/00379727-99-24352. [DOI] [PubMed] [Google Scholar]
  4. BRAGDON J. H. Colorimetric determination of blood lipides. J Biol Chem. 1951 Jun;190(2):513–517. [PubMed] [Google Scholar]
  5. BYERS S. O., FRIEDMAN M. Bile acid metabolism, dietary fats, and plasma cholesterol levels. Proc Soc Exp Biol Med. 1958 Jul;98(3):523–526. doi: 10.3181/00379727-98-24094. [DOI] [PubMed] [Google Scholar]
  6. BYERS S. O., FRIEDMAN M., HOMER R. An evaluation of potassium iodide as a therapeutic agent in the treatment of experimental hypercholesteremia and atherosclerosis. J Clin Invest. 1956 Sep;35(9):1015–1024. doi: 10.1172/JCI103347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BYERS S. O., FRIEDMAN M., MICHAELIS F. Observations concerning the production and excretion of cholesterol in mammals; I. Plasma cholesterol after bile duct ligation and free cholesterol injection. J Biol Chem. 1950 May;184(1):71–75. [PubMed] [Google Scholar]
  8. BYERS S. O., FRIEDMAN M. Production and excretion of cholesterol in mammals. VII. Biliary cholesterol; increment and indicator of hepatic synthesis of cholesterol. Am J Physiol. 1952 Feb;168(2):297–302. doi: 10.1152/ajplegacy.1952.168.2.297. [DOI] [PubMed] [Google Scholar]
  9. BYERS S. O., FRIEDMAN M., ST GEORGE S. Cholesterol metabolism. Annu Rev Biochem. 1956;25:613–640. doi: 10.1146/annurev.bi.25.070156.003145. [DOI] [PubMed] [Google Scholar]
  10. EMERSON R. J., VAN BRUGGEN J. T. Acetate metabolism: effects of tracer concentration. Arch Biochem Biophys. 1958 Oct;77(2):467–477. doi: 10.1016/0003-9861(58)90093-6. [DOI] [PubMed] [Google Scholar]
  11. FRIEDMAN M., BYERS S. O., MICHAELIS F. Bile acid content of rat bile and of normal and icteric rat plasma. Am J Physiol. 1951 Mar;164(3):786–788. doi: 10.1152/ajplegacy.1951.164.3.786. [DOI] [PubMed] [Google Scholar]
  12. FRIEDMAN M., BYERS S. O., MICHAELIS F. Observations concerning production and excretion of cholesterol in mammals. II. Excretion of bile in the rat. Am J Physiol. 1950 Sep;162(3):575–578. doi: 10.1152/ajplegacy.1950.162.3.575. [DOI] [PubMed] [Google Scholar]
  13. FRIEDMAN M., BYERS S. O., SHIBATA E. Observations concerning the production and excretion of cholesterol in mammals. X. Factors affecting the absorption and fate of ingested cholesterol. J Exp Med. 1953 Aug;98(2):107–117. doi: 10.1084/jem.98.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. GALBRAITH P. A., PERRY W. F., BEAMISH R. E. Effect of nicotinic acid on serum-lipids in normal and atherosclerotic subjects. Lancet. 1959 Jan 31;1(7066):222–223. doi: 10.1016/s0140-6736(59)90050-9. [DOI] [PubMed] [Google Scholar]
  15. HARTROFT W. S. Abnormal fat transport. Diabetes. 1958 May-Jun;7(3):221–229. doi: 10.2337/diab.7.3.221. [DOI] [PubMed] [Google Scholar]
  16. MERRILL J. M., LEMLEY-STONE J. Effects of nicotinic acid on serum and tissue cholesterol in rabbits. Circ Res. 1957 Nov;5(6):617–619. doi: 10.1161/01.res.5.6.617. [DOI] [PubMed] [Google Scholar]
  17. PARSONS W. B., Jr, ACHOR R. W., BERGE K. G., MCKENZIE B. F., BARKER N. W. Changes in concentration of blood lipids following prolonged administration of large doses of nicotinic acid to persons with hypercholesterolemia: preliminary observations. Proc Staff Meet Mayo Clin. 1956 Jun 27;31(13):377–390. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES