Figure 4. Structures of BF2*2101 with different peptides show several modes of promiscuous binding through remodelling of the binding site.
Left panels, top down view with peptide as sticks (N-terminus to the left; carbon atoms, yellow; nitrogen atoms, blue; oxygen atoms, red) and class I molecule as solid surface (grey except for positions of Asp24 side chain oxygen atoms in pink and Arg9 side chain nitrogen atoms as cyan). Right panels, side view from α2 domain side with peptide, Asp24 and Arg9 as sticks (hydrogen bonds, dotted lines; carbon atoms of Asp24 and Arg9, white; all else as in left panels). (A) GHAEEYGAETL (peptide P316; PDB 3BEV); (B) REVDEQLLSV (P330; 3BEW); (C) TNPESKVFYL (P458; 2YEZ); (D) TAGQEDYDRL (P394; 4D0B); (E) TAGQSNYDRL (P399; 4D0C); (F) YELDEKFDRL (P400; 4CVZ).