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. 1987 Dec;80(6):1706–1711. doi: 10.1172/JCI113261

Molecular analysis of a variant type of familial amyloidotic polyneuropathy showing cerebellar ataxia and pyramidal tract signs.

H Furuya 1, K Yoshioka 1, H Sasaki 1, Y Sakaki 1, M Nakazato 1, H Matsuo 1, A Nakadai 1, S Ikeda 1, N Yanagisawa 1
PMCID: PMC442443  PMID: 3479441

Abstract

A Japanese family with atypical type I familial amyloidotic polyneuropathy (FAP) in Iiyama, Japan was studied. Most of the family members have dysfunctions in the central nervous system, in addition to typical symptoms of type I FAP. The transthyretin (TTR, also called prealbumin) gene of the atypical FAP(FAP-IY) was analyzed with recombinant DNA techniques and a RIA method. FAP-IY was found to have the mutation responsible for the methionine-for-valine substitution at position 30 of TTR, as in the case of typical type I FAP. However, analysis of DNA polymorphisms in the TTR locus showed that FAP-IY has a genetic background differing from that of the typical type I FAP. These observations lead to the consideration that a genetic factor(s) involved in the dysfunction of the central nervous system may locate in a chromosome region in close proximity to the TTR gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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