In Fig 3C, the error bars are incorrect. Please see the corrected Fig 3 below.
Fig 3. Exhaustion in cumulative t-PA release.
In Panel A, the Control-1 (filled diamond, n = 16) and Control-2 (open diamond, n = 15) measurements show a pattern of exhaustion during the second stimulated t-PA release, starting early and continued throughout the sequence. Panel B shows the VPA treated group, with VPA-1 (filled square, n = 15) and VPA-2 (open square, n = 15) observations compared. There is no decrease observed in the second measurement until after 18 minutes. Panel C demonstrates a percent of the second measurement sequence compared to the first for both Control (filled triangles) and VPA (open triangles) (n = 13, where data was available for all measurements, treated and non-treated for the first and second sequences on both days). Minute 3 ratios reflect relatively small cumulative sums, possibly explaining the larger variation in the groups in Panel C. Data are presented as mean with 95% confidence intervals. * indicates p value less than 0.05 using repeated paired t tests.
Reference
- 1. Svennerholm K, Haney M, Biber B, Ulfhammer E, Saluveer O, Larsson P, et al. (2015) Histone Deacetylase Inhibition Enhances Tissue Plasminogen Activator Release Capacity in Atherosclerotic Man. PLoS ONE 10(3): e0121196 doi: 10.1371/journal.pone.0121196 [DOI] [PMC free article] [PubMed] [Google Scholar]

