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. 1988 Jun;81(6):1804–1809. doi: 10.1172/JCI113523

Age and bone mass as predictors of fracture in a prospective study.

S L Hui 1, C W Slemenda 1, C C Johnston Jr 1
PMCID: PMC442628  PMID: 3384952

Abstract

To study the effect of bone mass on the risk of fracture, we followed 521 Caucasian women over an average of 6.5 yr and took repeated bone mass measurements at the radius. We observed 138 nonspinal fractures in 3,388 person-yr. The person-years of follow-up and the incident fractures were cross-classified by age and bone mass. The incidence of fracture was then fitted to a log-linear model in age and bone mass. It was found that incidence of fracture increased with both increasing age and decreasing radius bone mass. When subsets of fractures were examined it was found that age was a stronger predictor of hip fractures, whereas midshaft radius bone mass was a stronger predictor of fractures at the distal forearm. We concluded that bone mass is a useful predictor of fractures but that other age-related factors associated with fractures need to be identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cummings S. R. Are patients with hip fractures more osteoporotic? Review of the evidence. Am J Med. 1985 Mar;78(3):487–494. doi: 10.1016/0002-9343(85)90343-2. [DOI] [PubMed] [Google Scholar]
  2. Daly P. J., Fitzgerald R. H., Jr, Melton L. J., Ilstrup D. M. Epidemiology of ankle fractures in Rochester, Minnesota. Acta Orthop Scand. 1987 Oct;58(5):539–544. doi: 10.3109/17453678709146395. [DOI] [PubMed] [Google Scholar]
  3. Gordon T., Kannel W. B. Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study. JAMA. 1972 Aug 14;221(7):661–666. [PubMed] [Google Scholar]
  4. Mazess R. B. On aging bone loss. Clin Orthop Relat Res. 1982 May;(165):239–252. [PubMed] [Google Scholar]
  5. Melton L. J., 3rd, Sampson J. M., Morrey B. F., Ilstrup D. M. Epidemiologic features of pelvic fractures. Clin Orthop Relat Res. 1981 Mar-Apr;(155):43–47. [PubMed] [Google Scholar]
  6. Melton L. J., 3rd, Wahner H. W., Richelson L. S., O'Fallon W. M., Riggs B. L. Osteoporosis and the risk of hip fracture. Am J Epidemiol. 1986 Aug;124(2):254–261. doi: 10.1093/oxfordjournals.aje.a114383. [DOI] [PubMed] [Google Scholar]
  7. Nelson E. L., Melton L. J., 3rd, Annegers J. F., Laws E. R., Offord K. P. Incidence of skull fractures in Olmsted County, Minnesota. Neurosurgery. 1984 Sep;15(3):318–324. doi: 10.1227/00006123-198409000-00005. [DOI] [PubMed] [Google Scholar]
  8. Owen R. A., Melton L. J., 3rd, Johnson K. A., Ilstrup D. M., Riggs B. L. Incidence of Colles' fracture in a North American community. Am J Public Health. 1982 Jun;72(6):605–607. doi: 10.2105/ajph.72.6.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rose S. H., Melton L. J., 3rd, Morrey B. F., Ilstrup D. M., Riggs B. L. Epidemiologic features of humeral fractures. Clin Orthop Relat Res. 1982 Aug;(168):24–30. [PubMed] [Google Scholar]
  10. Slemenda C., Hui S. L., Longcope C., Johnston C. C. Sex steroids and bone mass. A study of changes about the time of menopause. J Clin Invest. 1987 Nov;80(5):1261–1269. doi: 10.1172/JCI113201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smith D. M., Khairi M. R., Johnston C. C., Jr The loss of bone mineral with aging and its relationship to risk of fracture. J Clin Invest. 1975 Aug;56(2):311–318. doi: 10.1172/JCI108095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wasnich R. D., Ross P. D., Heilbrun L. K., Vogel J. M. Selection of the optimal skeletal site for fracture risk prediction. Clin Orthop Relat Res. 1987 Mar;(216):262–269. [PubMed] [Google Scholar]

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