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. 2015 Feb 20;29(5):699–702. doi: 10.1038/eye.2014.344

Macular hole in retinitis pigmentosa patients: microincision vitrectomy with polydimethylsiloxane as possible treatment

E M Vingolo 1, S Valente 1, E Gerace 1, L Spadea 1, M Nebbioso 2,*
PMCID: PMC4429268  PMID: 25697459

Abstract

Purpose

To investigate long-term retinal changes after microincision pars plana vitrectomy surgery (MIVS) for macular hole (MH) in retinitis pigmentosa (RP) patients—retrospective and observational study.

Methods

Three RP patients suffering from MH were evaluated by means of best corrected visual acuity, anterior and posterior binocular examination, spectralis high-resolution optical coherence tomography, MP-1 microperimetry (MP-1), and full-field electroretinogram (ERG), before MIVS and during the 36-month follow-up. Patients underwent simultaneous MIVS and microincision cataract surgery; IOL was positioned in capsular bag. Patients were hospitalised for 2 days after the surgery. Surgical procedure was performed according the following schedule: surgical removal of crystalline lens, MIVS with 23-gauge sutureless system trocars, core vitreous body removal, peeling of the inner limiting membrane, and balanced sterile saline solution-air-micro-structured polydimethylsiloxane (PDMS) exchange. PDMS tamponade, after 6 months starting from MIVS, was removed.

Results

In all patients visual acuity increased after vitrectomy as a consequence of complete MH closure and restoration of retinal architecture. None of the patients developed ocular hypertension, or re-opening of MH during the 3-year follow-up. MP-1 bivariate contour ellipse area was reduced in its dimensions and improved in all patients demonstrating a better fixation.

Conclusions

MIVS could be an effective treatment in RP patients with MH if medical therapy is not applicable or not sufficient. Finally more studies will be needed to improve knowledge about this genetic disease.

Introduction

Retinitis pigmentosa (RP) includes a wide group of different degenerative diseases of the outer retina caused by gene abnormalities on several chromosomes and that leads to legal blindness in 1/4000.1 An estimated 1.5 million people are affected around the world. Some patients become blind as early as age 30; the majority of the patients are legally blind by age 60 with a central visual field diameter <20 degrees.1, 2, 3 The outer segment of photoreceptors are usually damaged in very early stage of the disease, while the macula appears spared from the degenerative process for a long time.2 Frequently the presence of liquid leakage from retinal capillaries4 causes cystoid macular oedema (CME) and/or cells migration in the vitreous body.5

Oishi et al6 classified the status of the inner segment/outer segment junction (IS/OS) as being absent, discontinuous, or distinct. As a consequence of chronic blood retinal barrier breakdown, which is reported to occur in 8–50% of the instances, the inner surface of the retina may present irregularities of the inner limiting membrane (ILM) or iperreflectivity of vitreoretinal interface.4, 5 Macular cysts tend to be confluent in some cases and, in combination with ILM wrinkling, sometimes may lead to the formation of macular hole (MH) encompassing different stages (from I to IV according to Gass classification), that in RP patients is present in 4–8% of eyes with different shapes and gradation.5 Consequently few reports of MH surgical treatment in RP patients are present in the literature and usually involve small number of eyes treated with pars plana vitrectomy.7, 8

The purpose of this study was to evaluate the morphological and functional outcomes of microincision pars plana vitrectomy surgery (MIVS) associated to ILM peeling technique in RP patients with MH when medical therapy is not applicable or not effective.

Methods

The clinical charts of 3 RP patients suffering from MH secondary to chronic CME and tangential vitreoretinal tractions, who underwent 23-gauge MIVS (ACCURUS vitrectomy system ALCON Inc., Irvine, CA, USA) were evaluated retrospectively (Tables 1 and 2). These patients were unresponsive to conventional medical treatment based on carbonic anhydride inhibitors and non-steroidal anti-inflammatory drugs or steroids.

Table 1. Patients of the Referral Centre for Inherited Retinal Diseases.

Patients age BCVA eye Cataract SD-OCT foveal Parafoveal thickness MP-1 BCEA IOP (mm Hg)
Data before surgery treatment
 G.O. (M) 34 yrs 6/20 RE Posterior subcapsular MH III/IV 451 μm 0.42 14
 A.S. (M) 49 yrs 8/20 LE Nuclear/posterior subcapsular MH II/III 350 μm 0.54 12
 T.G. (F) 37 yrs 2/20 RE Posterior subcapsular MH IV 440 μm 1.34 14
             
Data after vitrectomy: MICS/MIVS/PDMS
 G.O. 10/20 Phaco+IOL 295 μm 350 μm 0.28 17
 A.S. 14/20 Phaco+IOL 278 μm 295 μm 0.25 16
 T.G. 4/20 Phaco+IOL 290 μm 350 μm 0.98 17
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Abbreviations: BCEA, bivariate contour ellipse area in degrees (parafoveal fixation area); BCVA, best corrected visual acuity; F, female; IOP, intraocular pressure; LE, left eye; M, male; MH, macular hole (grade according to Gass classification); MICS, microincision cataract surgery; MIVS, microincision pars plana vitrectomy surgery; MP-1, microperimetry; PDMS, polydimethylsiloxane; Phaco+IOL, phacoemulsification with intraocular lens; RE, right eye; SD-OCT, spectral-domain optical coherence tomography (central and paracentral retinal thickness); T.G., patient with diagnosis of Usher syndrome.

Table 2. Exams performed before and after vitrectomy.

Exams performed
BCVA Snellen and Bailey–Lowson EDTRS charts Anterior and posterior binocular examination SD-OCT HRA (Heidelberg Engineering, Heidelberg, Germany) and Cirrus HD-OCT (Zeiss Meditec, Inc., Dublin, CA, USA) Full-field ERG Stimulator MV Monitor Mon-Pack 120 Metrovision (Metrovision, Pérenchies, France) MP-1 microperimetry (Nidek Technologies, Padua, Italy (I))
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Abbreviations: BCVA, best corrected visual acuity; ERG, electroretinogram; SD-OCT, spectral-domain optical coherence tomography.

Surgical procedure was performed with a three-port pars plana vitrectomy, peeling of the ILM, and simultaneous cataract surgery by the same surgeon (EMV) under retrobulbar anaesthesia (Table 3). Betamethasone 0.1% eye drops were instilled for 10 days, followed by fluorometholone 0.1% for several weeks. After 6 months starting from MIVS, polydimethylsiloxane (PDMS) was removed. Patients were followed up for 36 months.

Table 3. Surgical procedure performed with a three-port pars plana vitrectomy under retrobulbar anaesthesia by the same surgeon (EMV), according to the following schedule and guidelines (the Declaration of Helsinki, Institutional Review Board, and informed consent was obtained from all subjects before enrolment).

Surgical procedure
Step 1 Surgical removal of the crystalline lens with MICS
Step 2 Phacoemulsification, aspiration, and IOL implantation
Step 3 Sclerotomy and MIVS with 23-gauge sutureless system trocars
Step 4 Core vitreous body removal with high aspiration level
Step 5 Posterior hyaloid and ILM peeling (disposable Eckardt forceps)
Step 6 BSS-air-micro-structured PDMS exchange in eyes with MH
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Abbreviations: BSS, balanced sterile saline solution; ILM, inner limiting membrane; IOL, intraocular lens; MICS, microincision cataract surgery; MIVS, microincision pars plana vitrectomy surgery; PDMS, polydimethylsiloxane.

Patient G

A 34-year-old male suffering from RP since the age of 14. Baseline best corrected visual acuity (BCVA) was 6/20 Snellen in the right eye. Slit lamp examination only revealed a posterior subcapsular cataract. In addition, spectral-domain optical coherence tomography (SD-OCT) demonstrated partial thickness MH and MP-1 reported a parafoveal fixation area with bivariate contour ellipse area (BCEA) of 0.42 degrees.

Due to the presence of MH (grade III/IV according to Gass classification), central retinal thickness was not considered, while parafoveal retinal thickness was 451 μm (Figure 1a). After vitrectomy, BCVA increased to 10/20 Snellen. SD-OCT showed a considerable reduction in parafoveal retinal thickness, and demonstrated a central retinal thickness of 295 μm (Figure 1b). BCEA decreased to a final value of 0.28 degrees.

Figure 1.

Figure 1

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Retinitis pigmentosa (RP) in G.O. patient. (a) Macular hole (MH) grade III/IV, according to Gass classification, as shown by spectral-domain optical coherence tomography (SD-OCT) before surgery. Parafoveal retinal thickness was 451 μm. (b) After surgery, the MH closed and the central retinal thickness was 295 μm.

Patient A

A 49-year-old male suffering from RP since the age 17. Baseline BCVA was 8/20 Snellen in the left eye. Nuclear and posterior subcapsular cataract was present at slit lamp examination. A partial thickness MH (grade II/III according to Gass classification) was demonstrated by SD-OCT. MP-1 reported a parafoveal fixation area with BCEA of 0.54 degrees at baseline. The parafoveal retina measured 350 μm in thickness. Postoperative VA increased to 14/20 Snellen. Central retinal thickness was 278 μm. BCEA after MH resolution was of 0.25 degrees.

Patient T

A 37-year-old woman with diagnosis of Usher syndrome. Baseline BCVA was 2/20 Snellen in the right eye. Posterior subcapsular cataract was observed biomicroscopically. SD-OCT showed a full thickness MH. A parafoveal fixation area with BCEA of 1.34 degrees at baseline was demonstrated with MP-1. Parafoveal retinal thickness was 440 μm. Postoperatively, VA increased to 4/20 Snellen. SD-OCT showed a reduction in parafoveal retinal thickness, and a central retinal thickness of 290 μm. BCEA decreased to 0.98 degrees.

Discussion

MH in RP patients is caused by chronic CME, incomplete vitreous detachment, and traction of condensed vitreous strands.7, 8 In exceptional cases, spontaneous resolution of a full thickness MH may occur.8, 9

Complete MH closure and restoration of retinal architecture in our patients lead to increased VA postoperatively and reduced BCEA with better fixation (Figure 1a and b).

Likewise an interesting study of Mahmoud et al10 showed that a combined lensectomy and vitrectomy procedure in P347L transgenic pigs was associated with retention of a significantly greater number of outer nuclear layer nuclei than in unoperated fellow eyes. Authors stated that consistent with the results obtained from other studies, the preservation of photoreceptors after surgery may be explained by the action of some diffusible substances or growth factors originating from the stimulated iris, ciliary body, and the retina.11 They could be: basic fibroblast growth factor (bFGF), neurotrophic growth factor (CNTF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and lens-epithelium-derived growth factor (LEGF).11, 12, 13

Moreover, Mahomoud et al10 and Schori et al14 showed that an autoimmune response by lymphocytes and cytokines may be involved in the rescue process of retinal cells degeneration 8 weeks after surgery.

On the other hand, the development of narrow-gauge transconjunctival vitrectomy systems has improved the visual recovery following surgery. We think that, at this stage in our knowledge, removal of any vitreomacular traction with peeling of the ILM is probably the main reason for visual improvement and better fixation postoperatively. Recently Ocriplasmin, by degrading laminin and fibronectin at the vitreoretinal interface, may allow induction of posterior vitreous detachment in a non-invasive manner.

Furthermore, additional research is still needed for the greater understanding of the pathophysiology underlying the development of vitreomacular traction and idiopathic MH in RP patients too.15, 16 Even if the present report is on few patients, our limited experience suggests that MIVS could be an effective therapy for MH in tapetoretinal dystrophies, and according to Sandeep et al8, 17, 18, 19, 20 PDMS could be useful compared with air-gas tamponade since RP patients have visual field restriction that can cause movement and posture problems thus facilitating a recurrence of the disease. However, further evidence may be needed to confirm our preliminary findings.

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The authors declare no conflict of interest.

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