Figure 8.

Summary of the sexually dimorphic TRβ1-positive cell zone during remodeling of the adrenal inner cortex. A, TRβ1-positive cells (blue) appear in the inner cortex prior to expression of 20αHSD. At juvenile stages, 20αHSD-positive X-zone cells appear as an inner subset of TRβ1-positive cells (red and blue). In males, TRβ1-positive cells regress at puberty, whereas in females, this cell population persists into adulthood. B, Hyperthyroidism induces cellular hypertrophy and expansion of the inner cortex. Many inner cortical cells also ectopically express the outer cortical marker AKR1B7 (orange outline). *, Response to T₃ does not occur in mature male mice after regression of the TRβ1-positive inner cortical zone.