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. 1992 Jul;90(1):156–159. doi: 10.1172/JCI115830

Detection of enteroviral RNA in idiopathic dilated cardiomyopathy and other human cardiac tissues.

L M Weiss 1, X F Liu 1, K L Chang 1, M E Billingham 1
PMCID: PMC443075  PMID: 1321839

Abstract

Enteroviruses have been considered to be a possible cause of idiopathic dilated cardiomyopathy. We used a polymerase chain reaction methodology for the identification of enteroviral RNA in an attempt to provide evidence of a role for enteroviruses in the pathogenesis of idiopathic dilated cardiomyopathy. The methodology was shown to identify a wide variety of enteroviruses with a sensitivity up to 0.1-1 plaque-forming units/gram of tissue. 5 of 11 cases (45%) of idiopathic dilated cardiomyopathy, as well as 9 of 24 cases (38%) of a wide variety of other cardiac conditions (including normal heart), were positive for enteroviral nucleic acid sequences; all eight control cases of breast carcinoma tested were negative. These results suggest that both the normal and abnormal heart may represent a site of latent or low-grade persistent enteroviral infection, and that the mere presence of enteroviral nucleic acid sequences is not specifically associated with idiopathic dilated cardiomyopathy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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