Table 4.
Multivariate analysis for treatment failure
| Variable | Treatment failure at day 7: odds ratio (95% CI)* | |
|---|---|---|
| Univariate | Multivariate | |
| Age | 1.02 (1 to 1.03) | 1.01 (0.99 to 1.03) |
| Charlson score | 1.24 (1.09 to 1.42) | 1.15 (0.99 to 1.35) |
| Bedridden† | 1.96 (1.06 to 3.65) | 0.80 (0.36 to 1.76) |
| Chronic obstructive pulmonary disease | 2.16 (1.05 to 4.45) | 0.76 (0.30 to 1.90) |
| Previous operation‡ | 0.49 (0.28 to 0.83) | 0.52 (0.28 to 0.96) |
| Mechanical ventilation† | 5.98 (2.49 to 14.3) | 5.02 (1.62 to 15.6) |
| SOFA score† | 1.41 (1.2 to 1.66) | 1.15 (0.94 to 1.40) |
| Bacteraemia | 2.71 (1.57 to 4.67) | 2.24 (1.20 to 4.18) |
| Trimethoprim-sulfamethoxazole arm | 1.61 (0.94 to 2.75) | 2.00 (1.09 to 3.65) |
SOFA=Sequential Organ Failure Assessment.
*Hosmer-Lemeshow P=0.08; area under receiver operating characteristics curve 0.75 (95% CI 0.68 to 0.82).
†Variables documented at infection onset; SOFA analysed as continuous variable.
‡In 30 days before infection.