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. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Drugs. 2012 May 7;72(7):907–916. doi: 10.2165/11632870-000000000-00000

Table 2.

Pharmacotherapeutic Options for Neonatal PDA

Drug Dosing Regimen
Indomethacin Prophylaxis
[12, 54, 74-76]

  1. Short 3-dose course of prophylactic indomethacin (0.2, 0.1, 0.1 mg/kg, administered at 24-hour intervals) OR

  2. Extended 6-dose course (0.2, 0.1, 0.1, 0.1, 0.1, 0.1 mg/kg, at 24-hour intervals) starting within 15 hours of birth OR

  3. 3 dose course of 0.1mg/kg IV at 24-hour intervals
Indomethacin Treatment
[100]

  1. 1st dose: 0.2 - 0.3 mg/kg IV

    2nd dose: 0.2 mg/kg IV Q 12-24 hours after 1st dose if PDA persists

    3rd dose: 0.2 mg/kg IV 12-24 hours after 2nd dose if PDA persists OR

  2. 0.2 mg/kg/dose PO/IV for three doses given at 12 hourly intervals
Ibuprofen Prophylaxis [46]

  1. Oral suspension 10mg/kg; 5mg/k, 5mg/kg PO q 24hrs for symptomatic PDA
Ibuprofen Treatment [5, 84]

  1. Loading dose of 10mg/kg IV/PO on day 1, followed by 5mg/kg/dose at 24 hrs and 48 hrs subsequently OR

  2. Oral ibuprofen 10 mg/kg/dose for three doses given at 24 hourly intervals