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. 1979 Aug;25(2):521–525. doi: 10.1128/iai.25.2.521-525.1979

Persistent infection of human lymphoid and myeloid cell lines with herpes simplex virus.

C R Rinaldo Jr, B S Richter, P H Black, M S Hirsch
PMCID: PMC443576  PMID: 226478

Abstract

Herpes simplex virus (HSV) type 1 replicated and persisted in human T, B, and myeloid cell lines with different patterns of viral replication and various effects on cell growth. T cell line CEM supported the replication of HSV for over 400 days without detectable differences in cell growth as compared with uninfected cells. HSV persisted in B cell line NC37 and myeloid cell line K562 for up to 222 and 374 days, respectively, but led to a significant decrease in the number of viable cells by 7 weeks of infection. The average number of cells producing infectious virus was very low in these cell lines (range, 0.5 to 2.7+) compared with a larger proportion of cells exhibiting HSV antigens by immunofluorescence (range, 24 to 58%). In contrast, null cell line LAZ 221 failed to replicate HSV even though the viral infection led to a cessation of cell growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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