Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Virology. 2015 Apr 7;481:223–234. doi: 10.1016/j.virol.2015.02.023

Figure 1.

Figure 1

Structure of HCV IRES. Adapted from Tumban E, 2009 [58]. (A) Complete IRES construct containing stem-loop I-IV. The AUG start codon of the core protein is bordered; (B) Stem-loop IIIf and IV enlarged to show target sites for I19 and I20 at U329 and U343 (circled), respectively; (C) FLuc assay demonstrating that the intron targeting stem loop IV (I-SL IV) inhibited a near-complete IRES translation compared to those targeting stem loop IIIa (I-SL IIIa) and IIIb (I-SL-IIIb).