Crystal structure of bis­[(1-ammonio-1-phosphono­eth­yl)phospho­nato]tetra­aqua­cadmium dihydrate: a powder X-ray diffraction study

In the compound [CdL ₂(H₂O)₄]·2H₂O [L = (1-ammonio-1-phosphono­eth­yl)phospho­nate, C₂H₈NO₆P₂ ⁻], the Cd^II ion is situated on an inversion centre being coordinated by four aqua mol­ecules in the equatorial plane and two deprotonated phospho­nate O atoms from two L ligands in the axial positions in a distorted octa­hedral geometry. Each ligand L exists in a zwitterionic form, and with an intra­molecular O—H⋯O inter­action forming an S(6) ring motif and two intra­molecular N—H⋯O inter­actions each generating an S(5) ring motif. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds link complex mol­ecules into a three-dimensional network with voids of 38 ų filled with ordered lattice water mol­ecules, which are also involved in O—H⋯O hydrogen bonding.

Abstract

In the title compound, [CdL ₂(H₂O)₄]·2H₂O [L = (1-ammonio-1-phosphono­eth­yl)phospho­nate, C₂H₈NO₆P₂ ⁻], the Cd^II ion is situated on an inversion centre being coordinated by four aqua mol­ecules in the equatorial plane and two phosphonate O atoms from two deprotonated L ligands in the axial positions in a distorted octa­hedral geometry. The asymmetric unit contains one-half of the complex mol­ecule and one lattice water mol­ecule. The ligand L exists in a zwitterionic form, with a positive charge on the NH₃ group and a negative charge on the O atom of the non-coordinating phospho­nate group, and with an intra­molecular O—H⋯O inter­action forming an S(6) ring motif and two intra­molecular N—H⋯O inter­actions each generating an S(5) ring motif. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds link the complex mol­ecules into a three-dimensional network in which the voids of 38 ų are filled with ordered lattice water mol­ecules, which are also involved in O—H⋯O hydrogen bonding.

Chemical context  

As a result of of their inhibitory effect on bone resorption, various types of bis­phospho­nates are used in the treatment of bone metastasis and several bone disorders such as Paget’s disease, and for the prevention of osteoporosis in post-menopausal women (Shaw & Bishop, 2005 ▸). Drugs prepared on the basis of bis­phospho­nates are highly efficient as a regulator of calcium metabolism and the immune response; they are used as anti-neoplastic, anti-inflammatory and anti­viral agents, drugs with analgesic effect and, as a component of toothpastes, bi­phospho­nates prevent the formation of tartar (Matkovskaya et al., 2001 ▸). Organic di­phospho­nic acids are potentially very powerful chelating agents, used in metal extractions and have been tested by the pharmaceutical industry for use as efficient drugs preventing calcification and inhibiting bone resorption (Matczak-Jon & Videnova-Adrabińska, 2005 ▸). Di­phospho­nic acids and their metal complexes are used in the treatment of Paget’s disease, osteoporosis and tumoral osteolysis (Szabo et al., 2002 ▸). However, it is still not clearly understood why small structural modification of bis­phospho­nates may lead to extensive alterations in their physicochemical, biological and toxicol­ogical characteristics (Matczak-Jon & Videnova-Adrabińska, 2005 ▸). Therefore, the structure determination of bis­phos­phon­ates is very important in order to understand the influence of structural modifications on their complex-forming abilities and physiological activities.

Structural commentary  

The asymmetric unit of the title compound, (I) (Fig. 1 ▸), contains one half of the complex mol­ecule [CdL ₂(H₂O)₄] [L = (1-ammonio-1-phosphono­eth­yl)phospho­nate] and one lattice water mol­ecule. All bond lengths and angles in (I) are normal and correspond to those observed in bis­phospho­nate complexes with transition metals (Shkol’nikova et al., 1991 ▸; Sergienko et al., 1997 ▸, 1999 ▸; Yin et al., 2005 ▸; Li et al., 2006 ▸; Li & Sun, 2007 ▸; Lin et al., 2007 ▸; Xiang et al., 2007 ▸; Dudko et al., 2009 ▸, 2010 ▸; Bon et al., 2010 ▸; Tsaryk et al., 2010 ▸, 2011 ▸). The Cd^II atom occupies a special position on an inversion centre and shows a slightly distorted octa­hedral coordination environment formed by two phospho­nic O atoms in trans positions and four aqua O atoms in the equatorial plane. The distorted octa­hedral coordination polyhedron is slightly compressed in the axial direction; the Cd1—O2 bond length is 0.1 Å shorter than the Cd1—O1W and Cd1—O2W bonds. The values of the axial O—Cd—O angles are in the range 80.1 (4)–99.9 (4)°, indicating a significant deviation from ideal values. The ligand L exists in a zwitterionic form, with a positive charge on the NH₃ group and a negative charge on the O atom of the non-coordinating phosphonate group, and with an intra­molecular O—H⋯O inter­action forming an S(6) ring motif and two intra­molecular N—H⋯O inter­actions each generating an S(5) ring motif (Table 1 ▸).

Figure 1.

The mol­ecular structure of (I), showing the atom-labelling scheme [symmetry code: (i) −x + 1, −y + 1, −z + 1]. Displacement spheres are drawn at the 50% probability level. H atoms are represented as small spheres of arbitrary radii. Dotted lines denote hydrogen bonds.

Table 1. Hydrogen-bond geometry (, ).

DHA	DH	HA	D A	DHA
O1H1O4	0.84	2.44	3.196(13)	151
N1H1NAO6i	0.87	2.07	2.828(13)	146
N1H1NBO4ii	0.88	2.16	2.872(15)	137
N1H1NCO3i	0.86	1.99	2.796(14)	156
O1WH1W1O2W i	0.82	2.39	2.987(13)	131
O5H5O6iii	0.84	1.79	2.551(12)	150
O1WH2W1O3i	0.82	1.96	2.758(15)	162
O2WH2W2O4iv	0.82	2.35	3.141(15)	162
O3WH1W3O3Wv	0.82	2.56	3.346(13)	160
O3WH2W3O3vi	0.82	2.13	2.833(14)	143

Symmetry codes: (i) ; (ii) ; (iii) ; (iv) ; (v) ; (vi) .

Supra­molecular features  

The crystal packing is illustrated in Fig. 2 ▸ as a projection of the unit cell along the b axis. Inter­molecular N—H⋯O and O—H⋯O hydrogen bonds (Table 1 ▸) link complex mol­ecules into a three-dimensional network in which the voids of 38 ų are filled with ordered lattice water mol­ecules, which are also involved in O—H⋯O hydrogen bonding (Table 1 ▸ and Fig. 2 ▸).

Figure 2.

A portion of the crystal packing viewed down the b axis. Dashed lines denote hydrogen bonds.

Synthesis and crystallization  

All reactions and manipulations were carried out in air with reagent grade solvents. 1-Amino­ethane-1,1-diyldi­phospho­nic acid was prepared according to the literature method of Rukiah & Assaad (2013 ▸). The title compound (I) was prepared by adding 10 ml of an 0.01 M CdCl₂ aqueous solution to 10 ml of a 0.02 M water solution of 1-amino­ethane-1,1-diyldi­phospho­nic acid. A crude product was obtained after two weeks of slow evaporation of the resulted solution. It was further purified by recrystallization from ethanol and water (1:3 v/v) at 273 K to produce the title compound (I) (white powder; m.p. > 623 K) in 80% yield. The IR spectrum was recorded on a Jasco FT–IR 300E instrument and the ¹H and ¹³C{¹H} NMR spectra were recorded on a Bruker Bio spin 400 spectrometer.

Spectroscopic data for (I):

¹H NMR (D₂O, p.p.m.): δ 1.67 (t, 3H, CH₃, J = 14 Hz). ¹³C{¹H} NMR (D₂O, p.p.m.): δ 20.5 (1C; CH₃), 54.7 (1C; C—CH₃). ³¹P{¹H} NMR (D₂O, p.p.m.): δ 13.61(2P; P—OH). IR (KBr, ν cm⁻¹): 3446.2 (NH₃), 2351.5 (POH), 1605.0 (O=P—O—H).

Refinement  

Crystal data, data collection and structure refinement details are summarized in Table 2 ▸. Compound (I) has a tendency to crystallize in the form of a very fine white powder. Since no single crystals of sufficient size and quality could be obtained, a crystal structure determination from laboratory powder X-ray diffraction data was performed. The powder sample was ground slightly in a mortar, loaded into two Mylar foils and fixed onto the sample holder with a mask of suitable inter­nal diameter (8.0 mm). The powder X-ray diffraction data were collected at room temperature with a STOE transmission STADI-P diffractometer using CuK_α1 radiation (λ= 1.54060 Å) selected with an incident-beam curved-crystal Ge(111) monochromator with a linear position-sensitive detector (PSD). The pattern was scanned over the angular range 6.0–90.0° (2θ). For pattern indexing, extraction of the peak positions was carried out with the program WinPLOTR (Roisnel & Rodríguez-Carvajal, 2001 ▸). Pattern indexing was performed with the program DICVOL4.0 (Boultif & Louër, 2004 ▸). The first 20 intense peaks of the powder pattern were indexed completely on the basis of a monoclinic cell. The figures of merit (de Wolff et al., 1968 ▸; Smith & Snyder, 1979 ▸) are sufficiently acceptable to support the obtained indexing results [M(20) = 37.1, F(20) = 78.5(0.0061, 42)]. The best estimated monoclinic space group was P2₁/c.

Table 2. Experimental details.

Crystal data
Chemical formula	[Cd(C2H8NO6P2)2(H2O)4]2H2O
M r	628.57
Crystal system, space group	Monoclinic, P21/c
Temperature (K)	298
a, b, c ()	10.69424(12), 5.61453(5), 17.2737(2)
()	100.7029(8)
V (3)	1019.12(2)
Z	2
Radiation type	Cu K 1, = 1.5406
(mm1)	12.41
Specimen shape, size (mm)	Flat sheet, 8 8
Data collection
Diffractometer	Stoe transmission STADI-P
Specimen mounting	Powder loaded into two Mylar foils
Data collection mode	Transmission
Scan method	Step
Absorption correction	For a cylinder mounted on the axis [GSAS (Larson Von Dreele, 2004 ▸) absorption/surface roughness correction: function No. 4, flat-plate transmission absorption correction, terms = 0.75850]
T min, T max	0.195, 0.310
2 values ()	2min = 6.00 2max = 89.98 2step = 0.02
Refinement
R factors and goodness of fit	R p = 0.029, R wp = 0.039, R exp = 0.025, R(F 2) = 0.04534, 2 = 2.624
No. of data points	4100
No. of parameters	133
No. of restraints	4
H-atom treatment	H-atom parameters not refined

Computer programs: WinXPOW (Stoe Cie, 1999 ▸), GSAS (Larson Von Dreele, 2004 ▸), EXPO2014 (Altomare et al., 2013 ▸), Mercury (Macrae et al., 2006 ▸) and publCIF (Westrip, 2010 ▸).

The powder pattern was subsequently refined with cell and resolution constraints (Le Bail et al., 1988 ▸) using the profile-matching option of the program FULLPROF (Rodríguez-Carvajal, 2001 ▸). The number of mol­ecules per unit cell was estimated to be Z = 2. The initial crystal structure was determined by direct methods using the program EXPO2014 (Altomare et al., 2013 ▸). The model found by this program was introduced into the program GSAS (Larson & Von Dreele, 2004 ▸) implemented in EXPGUI (Toby, 2001 ▸) for Rietveld refinement. The background was refined using a shifted Chebyshev polynomial with 20 coefficients. The effect of the asymmetry of the low-order peaks was corrected using a pseudo-Voigt description of the peak shape (Thompson et al., 1987 ▸), angle-dependent asymmetry with axial divergence (Finger et al., 1994 ▸) and microstrain broadening (Stephens, 1999 ▸). Two asymmetry parameters of this function, S/L and D/L, were both fixed at 0.0225 during this refinement. Intensities were corrected for absorption effects with a function for a plate sample in transmission geometry with μ·d value of 0.7585 (μ is the absorption coefficient and d is the sample thickness). These μ·d values were determined experimentally. The preferred orientation was modelled with 12 coefficients using a spherical harmonics correction (Von Dreele, 1997 ▸) of intensities. The use of the preferred orientation correction leads to a better mol­ecular geometry with better agreement factors. The value of obtained median texture index (1.0654) and the agreement factors in the refinement without texture correction (R _p = 0.053, R _wp = 0.073, R _exp = 0.025, R(F ²) = 0.011009 and χ² = 8.940) indicate that the preferred orientation improvement of the refinement is considerable.

Before the final refinement, the H atoms of the CH₃ and NH₃ groups were introduced on the basis of geometrical arguments. The hy­droxy and water H atoms were located using the program HYDROGEN (Nardelli, 1999 ▸) implemented in WinGX (Farrugia, 2012 ▸). The coordinates of all H atoms were refined with very strict soft restraints on bond lengths and angle until a suitable geometry was obtained, after that they were fixed in the final stage of the refinement. Four restraints for the central carbon atom (C—CH₃, C—NH₃ and two C—PO₃) on bond lengths were applied to normal values for these bonds. The final refinement cycles were performed varying isotropic displacement parameters for Cd and water O atoms, and fixed isotropic displacement parameters for P, C, N,O and H atoms. The final Rietveld plot is shown in Fig. 3 ▸.

Figure 3.

The final Rietveld plot for (I). Experimental intensities are indicated by dots, and the best-fit calculated (upper trace) and difference (lower trace) patterns are shown as solid lines. The vertical bars indicate the calculated positions of the Bragg peaks.

Supplementary Material

CCDC reference: 1051338

Additional supporting information: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Crystal data

[Cd(C2H8NO6P2)2(H2O)4]·2H2O	Z = 2
Mr = 628.57	F(000) = 636
Monoclinic, P21/c	Dx = 2.048 Mg m−3
Hall symbol: -P 2ybc	Cu Kα1 radiation, λ = 1.5406 Å
a = 10.69424 (12) Å	µ = 12.41 mm−1
b = 5.61453 (5) Å	T = 298 K
c = 17.2737 (2) Å	Particle morphology: fine powder
β = 100.7029 (8)°	white
V = 1019.12 (2) Å3	flat sheet, 8 × 8 mm

Data collection

Stoe transmission STADI-P diffractometer	Scan method: step
Radiation source: sealed X-ray tube	Absorption correction: for a cylinder mounted on the φ axis [GSAS (Larson & Von Dreele, 2004) absorption/surface roughness correction: function No. 4, flat-plate transmission absorption correction, terms = 0.75850]
Ge 111 monochromator	Tmin = 0.195, Tmax = 0.310
Specimen mounting: Powder loaded into two Mylar foils	2θmin = 6.00°, 2θmax = 89.98°, 2θstep = 0.02°
Data collection mode: transmission

Refinement

Refinement on Inet	Profile function: CW Profile function number 4 with 21 terms Pseudovoigt profile coefficients as parameterized in (Thompson et al., 1987). Asymmetry correction of (Finger et al., 1994). Microstrain broadening by (Stephens, 1999). #1(GU) = 0.000 #2(GV) = 0.000 #3(GW) = 7.136 #4(GP) = 0.000 #5(LX) = 2.421 #6(ptec) = 0.11 #7(trns) = 0.00 #8(shft) = 0.0000 #9(sfec) = 0.00 #10(S/L) = 0.0225 #11(H/L) = 0.0225 #12(eta) = 0.6026 #13(S400 ) = 1.2E-02 #14(S040 ) = 1.0E-01 #15(S004 ) = 1.2E-03 #16(S220 ) = 3.3E-02 #17(S202 ) = 6.7E-03 #18(S022 ) = 1.7E-02 #19(S301 ) = 1.1E-02 #20(S103 ) = 2.3E-03 #21(S121 ) = 1.5E-02 Peak tails are ignored where the intensity is below 0.0010 times the peak Aniso. broadening axis 0.0 0.0 1.0
Least-squares matrix: full	133 parameters
Rp = 0.029	4 restraints
Rwp = 0.039	H-atom parameters not refined
Rexp = 0.025	Weighting scheme based on measured s.u.'s
R(F2) = 0.04534	(Δ/σ)max = 0.03
χ2 = 2.624	Background function: GSAS Background function number 1 with 20 terms. Shifted Chebyshev function of 1st kind 1: 1216.00 2: -1325.95 3: 695.908 4: -224.478 5: 51.5854 6: -12.9254 7: 7.98937 8: -13.4593 9: 4.35490 10: 32.6578 11: -32.8988 12: -6.52632 13: -18.8133 14: 23.4504 15: -2.70081 16: -0.874623 17: -28.0163 18: 27.3423 19: 2.28961 20: -11.2631
4100 data points

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
C1	0.1555 (5)	0.3764 (12)	0.6381 (5)	0.015*
C2	0.2285 (11)	0.4133 (17)	0.7222 (5)	0.015*
H2a	0.17609	0.50488	0.75213	0.02*
H2b	0.3063	0.50177	0.72104	0.02*
H2c	0.24919	0.26144	0.74755	0.02*
N1	0.1274 (11)	0.6170 (16)	0.6028 (7)	0.02*
H1na	0.07228	0.68814	0.62561	0.025*
H1nb	0.09382	0.59823	0.55236	0.025*
H1nc	0.19624	0.69829	0.60678	0.025*
P1	0.2594 (5)	0.2361 (7)	0.5774 (3)	0.01*
O1	0.1897 (8)	0.2047 (13)	0.4907 (6)	0.01*
H1	0.11151	0.1887	0.48952	0.015*
O2	0.3659 (9)	0.4155 (15)	0.5771 (6)	0.01*
O3	0.3024 (8)	−0.0094 (16)	0.6124 (6)	0.01*
P2	0.0019 (4)	0.2252 (6)	0.6342 (3)	0.01*
O4	−0.0728 (9)	0.1904 (14)	0.5539 (6)	0.01*
O5	−0.0807 (8)	0.4058 (11)	0.6745 (5)	0.01*
H5	−0.06622	0.38276	0.7235	0.03*
O6	0.0255 (7)	−0.0022 (16)	0.6785 (5)	0.01*
Cd1	0.5	0.5	0.5	0.0093 (7)*
O1W	0.5302 (11)	0.8211 (15)	0.5815 (7)	0.029 (4)*
H1W1	0.56	0.91732	0.55443	0.03*
H2W1	0.47216	0.89419	0.59649	0.03*
O2W	0.6537 (10)	0.2995 (14)	0.5866 (6)	0.020 (3)*
H1W2	0.63758	0.22791	0.62489	0.03*
H2W2	0.72024	0.23865	0.57871	0.03*
O3w	0.5739 (11)	0.3949 (14)	0.7310 (6)	0.028 (3)*
H1W3	0.54032	0.26314	0.72841	0.03*
H2W3	0.5752	0.43812	0.77663	0.03*

Geometric parameters (Å, º)

C1—C2	1.530 (12)	P2—O5	1.588 (7)
C1—N1	1.490 (12)	P2—O6	1.486 (9)
C1—P1	1.840 (9)	O5—H5	0.842
C1—P2	1.839 (7)	Cd1—O2	2.183 (8)
C2—H2a	0.976	Cd1—O2i	2.183 (8)
C2—H2b	0.972	Cd1—O1W	2.274 (9)
C2—H2c	0.965	Cd1—O1Wi	2.274 (9)
N1—H1na	0.865	Cd1—O2W	2.300 (10)
N1—H1nb	0.885	Cd1—O2Wi	2.300 (10)
N1—H1nc	0.858	O1W—H1W1	0.817
P1—O1	1.555 (11)	O1W—H2W1	0.824
P1—O2	1.521 (9)	O2W—H1W2	0.820
P1—O3	1.541 (9)	O2W—H2W2	0.823
O1—H1	0.838	O3w—H1W3	0.820
P2—O4	1.480 (10)	O3w—H2W3	0.823
C2—C1—N1	107.2 (7)	C1—P2—O6	108.2 (5)
C2—C1—P1	110.1 (6)	O4—P2—O5	104.3 (5)
C2—C1—P2	113.1 (7)	O4—P2—O6	112.3 (6)
N1—C1—P1	104.6 (5)	O5—P2—O6	112.2 (5)
N1—C1—P2	107.0 (6)	P2—O5—H5	109.2
P1—C1—P2	114.3 (4)	O2—Cd1—O2i	180.0
C1—C2—H2a	109.4	O2—Cd1—O1W	80.1 (4)
C1—C2—H2b	109.6	O2—Cd1—O1Wi	99.9 (4)
C1—C2—H2c	110.1	O2—Cd1—O2W	88.2 (3)
H2a—C2—H2b	108.6	O2—Cd1—O2Wi	91.8 (3)
H2a—C2—H2c	109.4	O2i—Cd1—O1W	99.9 (4)
H2b—C2—H2c	109.7	O2i—Cd1—O1Wi	80.1 (4)
C1—N1—H1na	109.5	O2i—Cd1—O2W	91.8 (3)
C1—N1—H1nb	108.0	O2i—Cd1—O2Wi	88.2 (3)
C1—N1—H1nc	110.1	O1W—Cd1—O1Wi	180.0
H1na—N1—H1nb	108.5	O1W—Cd1—O2W	89.0 (4)
H1na—N1—H1nc	111.4	O1W—Cd1—O2Wi	91.0 (4)
H1nb—N1—H1nc	109.1	O1Wi—Cd1—O2W	91.0 (4)
C1—P1—O1	111.5 (6)	O1Wi—Cd1—O2Wi	89.0 (4)
C1—P1—O2	104.5 (5)	O2W—Cd1—O2Wi	180.0
C1—P1—O3	109.1 (4)	Cd1—O1W—H1W1	101.2
O1—P1—O2	107.2 (5)	Cd1—O1W—H2W1	124.1
O1—P1—O3	109.4 (5)	H1W1—O1W—H2W1	104.3
O2—P1—O3	115.1 (6)	Cd1—O2W—H1W2	122.2
P1—O1—H1	109.4	Cd1—O2W—H2W2	129.1
P1—O2—Cd1	136.4 (6)	H1W2—O2W—H2W2	104.3
C1—P2—O4	114.8 (5)	H1W3—O3w—H2W3	104.3
C1—P2—O5	104.8 (4)
O1W—Cd1—O2—P1	168.8 (9)	O1—P1—C1—C2	−177.9 (6)
O2W—Cd1—O2—P1	−101.9 (8)	O2—P1—C1—C2	−62.3 (7)
O1Wi—Cd1—O2—P1	−11.2 (9)	O3—P1—C1—C2	61.3 (7)
O2Wi—Cd1—O2—P1	78.1 (8)	O4—P2—C1—P1	−54.2 (6)
O3—P1—O2—Cd1	84.9 (9)	O5—P2—C1—P1	−168.0 (5)
C1—P1—O2—Cd1	−155.4 (7)	O6—P2—C1—P1	72.1 (6)
O1—P1—O2—Cd1	−37.0 (9)	O4—P2—C1—N1	61.1 (8)
O1—P1—C1—P2	53.6 (6)	O5—P2—C1—N1	−52.7 (8)
O2—P1—C1—P2	169.2 (5)	O6—P2—C1—N1	−172.6 (7)
O3—P1—C1—P2	−67.2 (6)	O4—P2—C1—C2	178.9 (6)
O1—P1—C1—N1	−63.1 (7)	O5—P2—C1—C2	65.0 (7)
O2—P1—C1—N1	52.5 (8)	O6—P2—C1—C2	−54.9 (7)
O3—P1—C1—N1	176.1 (7)

Symmetry code: (i) −x+1, −y+1, −z+1.

Hydrogen-bond geometry (Å, º)

D—H···A	D—H	H···A	D···A	D—H···A
O1—H1···O4	0.84	2.44	3.196 (13)	151
O1—H1···O4ii	0.84	2.27	2.592 (12)	103
N1—H1NA···O5	0.87	2.53	2.986 (14)	114
N1—H1NA···O6iii	0.87	2.07	2.828 (13)	146
N1—H1NB···O4iv	0.88	2.16	2.872 (15)	137
N1—H1NC···O2	0.86	2.53	2.899 (15)	107
N1—H1NC···O3iii	0.86	1.99	2.796 (14)	156
O1W—H1W1···O2Wiii	0.82	2.39	2.987 (13)	131
O5—H5···O6v	0.84	1.79	2.551 (12)	150
O1W—H2W1···O3iii	0.82	1.96	2.758 (15)	162
O2W—H1W2···O3W	0.82	2.27	2.833 (15)	126
O2W—H2W2···O4vi	0.82	2.35	3.141 (15)	162
O3W—H1W3···O3Wvii	0.82	2.56	3.346 (13)	160
O3W—H2W3···O3viii	0.82	2.13	2.833 (14)	143

Symmetry codes: (ii) −x, −y, −z+1; (iii) x, y+1, z; (iv) −x, −y+1, −z+1; (v) −x, y+1/2, −z+3/2; (vi) x+1, y, z; (vii) −x+1, y−1/2, −z+3/2; (viii) −x+1, y+1/2, −z+3/2.