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. 1994 Jul 19;91(15):7355–7359. doi: 10.1073/pnas.91.15.7355

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

S A Kliewer 1, B M Forman 1, B Blumberg 1, E S Ong 1, U Borgmeyer 1, D J Mangelsdorf 1, K Umesono 1, R M Evans 1
PMCID: PMC44398  PMID: 8041794

Abstract

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse. The three PPAR isoforms display widely divergent patterns of expression during embryogenesis and in the adult. Surprisingly, PPAR gamma and -delta are not activated by pirinixic acid (Wy 14,643), a potent peroxisome proliferator and activator of PPAR alpha. However, PPAR gamma and -delta are activated by the structurally distinct peroxisome proliferator LY-171883 and linoleic acid, respectively, indicating that each of the isoforms can act as a regulated activator of transcription. These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms.

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