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. 1972 Jan;1(1):1–5. doi: 10.1128/aac.1.1.1

Suppression of Immune and Hemopoietic Cellular Responses by Methisazone

T A McNeill 1, W A Fleming 1, Sheena F McClure 1, M Killen 1
PMCID: PMC444156  PMID: 4670426

Abstract

The antiviral drug methisazone (N-methylisatin β-thiosemicarbazone) was tested for its effect on immune responses to sheep erythrocytes and on hemopoietic colony-forming cell (granulocyte-macrophage progenitor cell) responses to complete Freund's adjuvant in mice. Suppressive activity was demonstrated in both systems, the immune system being more readily and more consistently susceptible. Evidence is presented which suggests that the insoluble particulate form of the drug has both stimulatory and suppressive effects on the colony-forming cell system, whereas the soluble form is only suppressive. Methisazone increased the mortality from ectromelia in adjuvant-treated animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAUER D. J., SADLER P. W. Derivatives of isatin beta-thiosemicarbazone with anti-viral chemotherapeutic activity against ectromelia infection. Nature. 1961 Jun 24;190:1167–1169. doi: 10.1038/1901167a0. [DOI] [PubMed] [Google Scholar]
  2. BAUER D. J., SHEFFIELD F. W. Antiviral chemotherapeutic activity of isatin beta-thiosemicarbazone in mice infected with rabbit-pox virus. Nature. 1959 Nov 7;184(Suppl 19):1496–1497. doi: 10.1038/1841496b0. [DOI] [PubMed] [Google Scholar]
  3. BAUER D. J., STVINCENT L., KEMPE C. H., DOWNIE A. W. PROPHYLACTIC TREATMENT OF SMALL POX CONTACTS WITH N-METHYLISATIN BETA-THIOSEMICARBAZONE (COMPOUND 33T57, MARBORAN). Lancet. 1963 Sep 7;2(7306):494–496. doi: 10.1016/s0140-6736(63)90230-7. [DOI] [PubMed] [Google Scholar]
  4. Bauer D. J. Clinical experience with the antiviral drug marboran (1-methylisatin 3-thiosemicarbazone). Ann N Y Acad Sci. 1965 Jul 30;130(1):110–117. doi: 10.1111/j.1749-6632.1965.tb12545.x. [DOI] [PubMed] [Google Scholar]
  5. Cho C. T., Bolano C. R., Kamitsuka P. S., Wenner H. A. Methisazone and monkey pox virus: studies in cell cultures, chick embryos, mice and monkeys. Am J Epidemiol. 1970 Aug;92(2):137–144. doi: 10.1093/oxfordjournals.aje.a121186. [DOI] [PubMed] [Google Scholar]
  6. LANDSMAN J. B., GRIST N. R. CONTROLLED TRIAL OF MARBORAN ON GROUP VACCINATED AGAINST SMALLPOX. Lancet. 1964 Feb 8;1(7328):330–330. doi: 10.1016/s0140-6736(64)92447-x. [DOI] [PubMed] [Google Scholar]
  7. McNeill T. A. Antigenic stimulation of bone marrow colony forming cells. 3. Effect in vivo. Immunology. 1970 Jan;18(1):61–72. [PMC free article] [PubMed] [Google Scholar]
  8. McNeill T. A., Killen M. Hemopoietic colony-forming cell responses in mice infected with ectromelia virus. Infect Immun. 1971 Oct;4(4):323–330. doi: 10.1128/iai.4.4.323-330.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McNeill T. A., Killen M. Role of hemopoietic colony-forming cell responses in the pathogenesis of ectromelia. Infect Immun. 1971 Oct;4(4):331–336. doi: 10.1128/iai.4.4.331-336.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McNeill T. A., Killen M. The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vivo. Immunology. 1971 Nov;21(5):751–759. [PMC free article] [PubMed] [Google Scholar]
  11. McNeill T. A. The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro. Immunology. 1971 Nov;21(5):741–750. [PMC free article] [PubMed] [Google Scholar]

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