Abstract
Methisazone (N-methylisatin β-thiosemicarbazone) was shown to inhibit the development of hemopoietic colonies in vitro when incorporated in the culture medium. The activity of methisazone was compared with that of several antimetabolic and antibiotic drugs. Although methisazone reduced the number of colonies, it did not affect the size of those colonies which did develop, and evidence is presented which shows that it acted only at the early stages of colony development. Some implications of these findings are briefly discussed.
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Selected References
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- Bauer D. J. Clinical experience with the antiviral drug marboran (1-methylisatin 3-thiosemicarbazone). Ann N Y Acad Sci. 1965 Jul 30;130(1):110–117. doi: 10.1111/j.1749-6632.1965.tb12545.x. [DOI] [PubMed] [Google Scholar]
- Bradley T. R., Sumner M. A. Stimulation of mouse bone marrow colony growth in vitro by conditioned medium. Aust J Exp Biol Med Sci. 1968 Oct;46(5):607–618. doi: 10.1038/icb.1968.167. [DOI] [PubMed] [Google Scholar]
- Cho C. T., Bolano C. R., Kamitsuka P. S., Wenner H. A. Methisazone and monkey pox virus: studies in cell cultures, chick embryos, mice and monkeys. Am J Epidemiol. 1970 Aug;92(2):137–144. doi: 10.1093/oxfordjournals.aje.a121186. [DOI] [PubMed] [Google Scholar]
- LANDSMAN J. B., GRIST N. R. CONTROLLED TRIAL OF MARBORAN ON GROUP VACCINATED AGAINST SMALLPOX. Lancet. 1964 Feb 8;1(7328):330–330. doi: 10.1016/s0140-6736(64)92447-x. [DOI] [PubMed] [Google Scholar]
- Magee W. E., Bach M. K. Biochemical studies on the antiviral activities of the isatin-beta-thiosemicarbazones. Ann N Y Acad Sci. 1965 Jul 30;130(1):80–91. doi: 10.1111/j.1749-6632.1965.tb12542.x. [DOI] [PubMed] [Google Scholar]
- Metcalf D., Foster R. Bone marrow colony-stimulating activity of serum from mice with viral-induced leukemia. J Natl Cancer Inst. 1967 Dec;39(6):1235–1245. [PubMed] [Google Scholar]
- Metcalf D. Studies on colony formation in vitro by mouse bone marrow cells. I. Continuous cluster formation and relation of clusters to colonies. J Cell Physiol. 1969 Dec;74(3):323–332. doi: 10.1002/jcp.1040740313. [DOI] [PubMed] [Google Scholar]
- Munro T. W., Sabina L. R. Inhibition of infectious bovine rhinotracheitis virus multiplication by thiosemicarbazones. J Gen Virol. 1970 Apr;7(1):55–63. doi: 10.1099/0022-1317-7-1-55. [DOI] [PubMed] [Google Scholar]
- Rao A. R., McFadzean J. A., Squires S. The laboratory and clinical assessment of an isothiazole thiosemicarbazone (M 2 b 7714) against pox viruses. Ann N Y Acad Sci. 1965 Jul 30;130(1):118–127. doi: 10.1111/j.1749-6632.1965.tb12546.x. [DOI] [PubMed] [Google Scholar]
- Sandeman T. F. Pilot trial of an antiviral agent in malignant disease. Br Med J. 1966 Sep 10;2(5514):625–627. doi: 10.1136/bmj.2.5514.625. [DOI] [PMC free article] [PubMed] [Google Scholar]