Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1972 Feb;1(2):123–134. doi: 10.1128/aac.1.2.123

Biosynthesis of Novobiocin by Streptomyces niveus

L A Kominek 1
PMCID: PMC444180  PMID: 4680802

Abstract

Streptomyces niveus in a chemically defined medium requires the inclusion of Krebs cycle acids for good growth. These acids are used in preference to glucose, and this results in diauxic growth. Studies with washed cells, cell-free extracts, and mutants of S. niveus were performed to determine the mode of synthesis of the individual ring systems of novobiocin and their linkage. A pathway for novobiocin synthesis is proposed on the basis of these experiments.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIRCH A. J., HOLLOWAY P. W., RICKARDS R. W. The biosynthesis of noviose, a branched-chain monosaccharide. Biochim Biophys Acta. 1962 Feb 12;57:143–145. doi: 10.1016/0006-3002(62)91090-9. [DOI] [PubMed] [Google Scholar]
  2. BULOCK J. D., POWELL A. J. SECONDARY METABOLISM: AN EXPLANATION IN TERMS OF INDUCED ENZYME MECHANISMS. Experientia. 1965 Jan 15;21:55–56. doi: 10.1007/BF02136383. [DOI] [PubMed] [Google Scholar]
  3. HOEKSEMA H., SMITH C. G. Novobiocin. Prog Ind Microbiol. 1961;3:91–139. [PubMed] [Google Scholar]
  4. Hessler E. J., Jahnke H. K. O-demethyldecarbamoylnovobiocin. J Med Chem. 1968 Nov;11(6):1228–1229. doi: 10.1021/jm00312a030. [DOI] [PubMed] [Google Scholar]
  5. Krulwich T. A., Ensign J. C. Alteration of glucose metabolism of Arthrobacter crystallopoietes by compounds which induce sphere to rod morphogenesis. J Bacteriol. 1969 Feb;97(2):526–534. doi: 10.1128/jb.97.2.526-534.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  7. Ng F. M., Dawes E. A. Regulation of enzymes of glucose metabolism by citrate in Pseudomonas aeruginosa. Biochem J. 1967 Sep;104(3):48P–48P. [PMC free article] [PubMed] [Google Scholar]
  8. SMITH R. M., PERRY J. J., PRESCOTT G. C., JOHNSON J. L., FORD J. H. Assay methods for novobiocin. Antibiot Annu. 1957;5:43–52. [PubMed] [Google Scholar]
  9. Szeszák F., Szabó G. Antibiotic production of hyphal fractions of Streptomyces griseus. II. Streptomycin production of different fractions obtained by density gradient centrifugation. Appl Microbiol. 1967 Sep;15(5):1010–1013. [PMC free article] [PubMed] [Google Scholar]
  10. TROLL W., LINDSLEY J. A photometric method for the determination of proline. J Biol Chem. 1955 Aug;215(2):655–660. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES