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. 1972 Feb;1(2):143–147. doi: 10.1128/aac.1.2.143

Effect of Antiviral Agents in Equine Abortion Virus-Infected Hamsters1

Melvin Lieberman a, Andrea Pascale a, Thomas W Schafer a, Paul E Came a
PMCID: PMC444183  PMID: 4376907

Abstract

Equine abortion virus, a member of the herpesvirus group, produces a lethal infection in hamsters. With this system, the protective effect of certain inhibitors of deoxyribonucleic acid viruses, inducers of interferon and exogenous interferon, was evaluated. Of the various agents studied, 9-β-d-arabinofuranosyladenine markedly suppressed mortality, and 5-iodo-2′-deoxyuridine, distamycin A, and N-ethylisatin β-thiosemicarbazone were inactive. Of the inducers tested, statolon, ultraviolet-irradiated Newcastle disease virus, and polyriboinosinic:polyribocytidylic acid (poly I:C) were protective, and endotoxin, polyacrylic acid, and polymethacrylic acid did not protect. Administration of exogenous interferon did not afford protection. Statolon and ultraviolet-irradiated Newcastle disease virus induced circulating interferon in hamsters, whereas poly I:C, endotoxin, and polyacrylic acid did not produce interferon. Because of the severity of the disease produced in hamsters by equine abortion virus, lack of protective activity by an agent in this system should not preclude possible efficacy against other members of the herpesvirus group.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atanasiu P., Barroeta M., Tsiang H., Favre S. Inhibition in vivo de la multiplication du virus rabique par un interféron endogène. Ann Inst Pasteur (Paris) 1970 Dec;119(6):767–777. [PubMed] [Google Scholar]
  2. BAUER D. J., SADLER P. W. The structure-activity relationships of the antiviral chemotherapeutic activity of isatin beta-thiosemicarbazone. Br J Pharmacol Chemother. 1960 Mar;15:101–110. doi: 10.1111/j.1476-5381.1960.tb01216.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DOLL E. R., BRYANS J. T., MCCOLLUM W. H., CROWE E. W. Propagation of equine abortion virus in Syrian hamsters. Cornell Vet. 1956 Jan;46(1):68–82. [PubMed] [Google Scholar]
  4. De Clercq E., Merigan T. C. Induction of interferon by nonviral agents. Arch Intern Med. 1970 Jul;126(1):94–108. doi: 10.1001/archinte.126.1.94. [DOI] [PubMed] [Google Scholar]
  5. FORCE E. E., STEWART R. C. EFFECT OF 5-IODO-2'-DEOXYURIDINE ON THE PATHOGENESIS OF COLUMBIA-SK VIRUS IN MICE. J Immunol. 1964 Nov;93:872–878. [PubMed] [Google Scholar]
  6. Frickey P. H. Markers differentiating type 3 parainfluenza virus grown at 25 and 37 C. Appl Microbiol. 1969 Apr;17(4):589–595. doi: 10.1128/am.17.4.589-595.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Glasgow L. A., Hanshaw J. B., Merigan T. C., Petralli J. K. Interferon and cytomegalovirus in vivo and in vitro. Proc Soc Exp Biol Med. 1967 Jul;125(3):843–849. doi: 10.3181/00379727-125-32220. [DOI] [PubMed] [Google Scholar]
  8. Gresser I., Bourali C., Thomas M. T., Falcoff E. Effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus. Proc Soc Exp Biol Med. 1968 Feb;127(2):491–496. doi: 10.3181/00379727-127-32723. [DOI] [PubMed] [Google Scholar]
  9. KAUFMAN H. E., NESBURN A. B., MALONEY E. D. IDU therapy of herpes simplex. Arch Ophthalmol. 1962 May;67:583–591. doi: 10.1001/archopht.1962.00960020583012. [DOI] [PubMed] [Google Scholar]
  10. Kaufman H. E., Ellison E. D., Townsend W. M. The chemotherapy of herpes iritis with adenine arabinoside and cytarabine. Arch Ophthalmol. 1970 Dec;84(6):783–787. doi: 10.1001/archopht.1970.00990040785018. [DOI] [PubMed] [Google Scholar]
  11. Larson V. M., Clark W. R., Hilleman M. R. Influence of synthetic (poly I:C) and viral double-stranded ribonucleic acids on adenovirus 12 oncogenesis in hamsters. Proc Soc Exp Biol Med. 1969 Jul;131(3):1002–1011. doi: 10.3181/00379727-131-34028. [DOI] [PubMed] [Google Scholar]
  12. Oh J. O. Sensitivity of Types 1 and 2 Herpesvirus hominis to an Interferon Inducer, Poly I:C. Infect Immun. 1971 Jun;3(6):847–848. doi: 10.1128/iai.3.6.847-848.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. POLLIKOFF R., LIEBERMAN M., LEM N. E., FOLEY E. J. ANTIVIRAL ACTIVITY OF N-ETHYLISATIN BETA-THIOSEMICARBAZONE IN VACCINIA-INFECTED MICE. J Immunol. 1965 May;94:794–804. [PubMed] [Google Scholar]
  14. RANDALL C. C., BRACKEN E. C. Studies on hepatitis in hamsters infected with equine abortion virus. I. Sequential development of inclusions and the growth cycle. Am J Pathol. 1957 Jul-Aug;33(4):709–727. [PMC free article] [PubMed] [Google Scholar]
  15. Rhim J. S., Huebner R. J. Comparison of the antitumor effect of interferon and interferon inducers. Proc Soc Exp Biol Med. 1971 Feb;136(2):524–529. doi: 10.3181/00379727-136-35304. [DOI] [PubMed] [Google Scholar]
  16. Schabel F. M., Jr The antiviral activity of 9-beta-D-arabinofuranosyladenine (ARA-A). Chemotherapy. 1968;13(6):321–338. doi: 10.1159/000220567. [DOI] [PubMed] [Google Scholar]
  17. Schardein J. L., Sidwel R. W. Antiviral activity of 9-beta-D-arabinofuranosyladenine. 3. Reduction in evidence of encephalitis in treated herpes Simplex-infected hamsters. Antimicrob Agents Chemother (Bethesda) 1968;8:155–160. [PubMed] [Google Scholar]
  18. Sidwell R. W., Dixon G. J., Schabel F. M., Jr, Kaump D. H. Antiviral activity of 9-beta-D-arabinofuranosyladenine. II. Activity against Herpes simplex keratitis in hamsters. Antimicrob Agents Chemother (Bethesda) 1968;8:148–154. [PubMed] [Google Scholar]
  19. Sloan B. J., Miller F. A., Ehrlich J., McLean I. W., Machamer H. E. Antiviral activity of 0-beta-D-arabinofuranosyladenine. IV. Activity against intracerebral herpes simplex virus infections in mice. Antimicrob Agents Chemother (Bethesda) 1968;8:161–171. [PubMed] [Google Scholar]
  20. Stewart W. E., 2nd, Scott W. D., Sulkin S. E. Relative sensitivities of viruses to different species of interferon. J Virol. 1969 Aug;4(2):147–153. doi: 10.1128/jvi.4.2.147-153.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. WAGNER R. R. Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus. Virology. 1961 Mar;13:323–337. doi: 10.1016/0042-6822(61)90152-0. [DOI] [PubMed] [Google Scholar]
  22. WERNER G. H., GANTER P., DE RATULD Y. STUDIES ON THE ANTIVIRAL ACTIVITY OF DISTAMYCIN A. Chemotherapy. 1964;13:65–79. doi: 10.1159/000220346. [DOI] [PubMed] [Google Scholar]

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