Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1972 Mar;1(3):210–214. doi: 10.1128/aac.1.3.210

Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

W Christopher Duncan 1, William R Holder 1, David P Roberts 1, John M Knox 1
PMCID: PMC444194  PMID: 4261553

Abstract

Spectinomycin hydrochloride, a new parenteral antibiotic prepared from Streptomyces spectabilis, was compared with standard U.S. Public Health Service-recommended dosages of aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in 353 men and 314 women. Of the 314 women, 130 had a pretreatment positive rectal culture. All diagnoses were proven by culture on Thayer-Martin selective medium. Minimal inhibitory concentrations of both drugs were determined. Single doses of 2 and 4 g of spectinomycin were compared with 2.4 million units of procaine penicillin in males and with both 2.4 and 4.8 million units of procaine penicillin in females. Both spectinomycin schedules, 2.4 million units of penicillin in males and 4.8 million units of penicillin in females, resulted in cure rates in excess of 90%. There were no failures at the rectal site only in those women with positive rectal cultures. There was no advantage to using the larger amount of spectinomycin in either sex.

Full text

PDF
210

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLARK J. W., Jr, YOBS A. R. EFFECT OF ACTINOSPECTACIN IN EXPERIMENTAL SYPHILIS IN THE RABBIT. I. EARLY LESION SYPHILIS. Br J Vener Dis. 1963 Sep;39:184–189. doi: 10.1136/sti.39.3.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CLARK J. W., Jr, YOBS A. R., POST W. E., Jr EFFECT OF ACTINOSPECTACIN (TROBICIN) IN EXPERIMENTAL SYPHILIS IN THE RABBIT. II. IN SUBCLINICAL INCUBATING SYPHILIS. Br J Vener Dis. 1964 Mar;40:53–54. doi: 10.1136/sti.40.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caldwell J. G., Price E. V., Pazin G. J., Cornelius C. E., 3rd Sensitivity and reproducibility of Thayer-Martin culture mddium in diagnosing gonorrhea in women. Am J Obstet Gynecol. 1971 Feb 1;109(3):463–468. doi: 10.1016/0002-9378(71)90346-2. [DOI] [PubMed] [Google Scholar]
  4. Cornelius C. E., 3rd, Domescik G. Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea. Br J Vener Dis. 1970 Jun;46(3):212–213. doi: 10.1136/sti.46.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lentz J. W., Nicholas L. Penicilloyl-polylysine intradermal testing for penicillin hypersensitivity. Br J Vener Dis. 1970 Dec;46(6):457–460. doi: 10.1136/sti.46.6.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Schmale J. D., Martin J. E., Jr, Domescik G. Observations on the culture diagnosis of gonorrhea in women. JAMA. 1969 Oct 13;210(2):312–314. [PubMed] [Google Scholar]
  7. Scott J., Stone A. H. Some observations on the diagnosis of rectal gonorrhoea in both sexes using a selective culture medium. Br J Vener Dis. 1966 Jun;42(2):103–106. doi: 10.1136/sti.42.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Shapiro L. H., Lentz J. W. Clinical evaluation of treatment of gonorrhea in the female. Am J Obstet Gynecol. 1967 Apr 1;97(7):968–973. doi: 10.1016/0002-9378(67)90525-x. [DOI] [PubMed] [Google Scholar]
  9. Sparling P. F., Yobs A. R., Billings T. E., Hackney J. F. Spectinomycin sulfate and aqueous procaine penicillin G in treatment of female gonorrhea. Antimicrob Agents Chemother (Bethesda) 1965;5:689–692. [PubMed] [Google Scholar]
  10. Wagner J. G., Novak E., Leslie L. G., Metzler C. M. Absorption, distribution, and elimination of spectinomycin dihydrochloride in man. Int Z Klin Pharmakol Ther Toxikol. 1968 Apr;1(4):261–285. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES