Table 3.

Association of left atrial size and recurrent ischemic stroke and recurrent cryptogenic or cardioembolic stroke

	Left atrial size	Model 1, Unadjusted, Hazard ratio (95% confidence interval)	Model 2* Hazard ratio (95% confidence interval)	Model 3** Hazard ratio (95% confidence interval)
Recurrent ischemic stroke of any subtype	Normal Left atrial size	reference	reference	reference
	Mild left atrial enlargement	1.15 (0.67-1.97)	1.10 (0.63-1.90)	1.06 (0.60-1.87)
	Moderate to severe left atrial enlargement	1.24 (0.61-2.52)	1.06 (0.51-2.19)	1.06 (0.48-2.30)
	Left atrial size (per SD+ increase)	1.09 (0.84-1.41)	1.03 (0.79-1.34)	1.03 (0.76-1.38)
Recurrent cardioembolic or cryptogenic stroke	Normal left atrial size	reference	reference	reference
	Mild left atrial enlargement	1.56 (0.64-3.84)	1.53 (0.61-3.80)	1.32 (0.51-3.39)
	Moderate to severe left atrial enlargement	4.35 (1.81-10.48)	3.83 (1.54-9.54)	2.83 (1.03-7.81)
	Left atrial size (per SD+ increase)	1.76 (1.25-2.48)	1.73 (1.21-2.49)	1.55 (1.01-2.37)

⁺SD: Standard Deviation

^*Adjusted for age, sex, and race-ethnicity;

^**Adjusted for age, sex, race-ethnicity, hypertension, diabetes, hypercholesterolemia, smoking, atrial fibrillation, and congestive heart failure