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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1972 Apr;1(4):358–362. doi: 10.1128/aac.1.4.358

Amoxicillin: In Vitro and Pharmacological Studies

Gerald P Bodey 1, Jane Nance 1
PMCID: PMC444222  PMID: 4598841

Abstract

Amoxicillin is a new semisynthetic penicillin which is active in vitro against gram-positive cocci (except penicillin G-resistant Staphylococcus aureus) and most isolates of Proteus mirabilis and Escherichia coli. Its in vitro activity is quite similar to ampicillin, but it produces higher serum levels after oral administration. The mean peak serum levels of amoxicillin in 11 normal volunteers were 2.30 μg/ml after 125 mg, 3.43 μg/ml after 250 mg, 6.75 μg/ml after 500 mg, and 9.90 μg/ml after 1 g. About 70% of the drug was excreted in the urine during the first 6 hr.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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