Abstract
An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N-methyl-desformimino derivative of antibiotic LL-AC541.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Borders D. B., Sax K. J., Lancaster J. E., Hausmann W. K., Mitscher L. A., Wetzel E. R., Patterson E. L. Structures of LL-AC541 and LL-AB664: new streptothricin-type antibiotics. Tetrahedron. 1970 Jul;26(13):3123–3133. doi: 10.1016/s0040-4020(01)92895-9. [DOI] [PubMed] [Google Scholar]
- Egorov G. A., Reshetov P. D., Khokhlov A. S. A method for the quantitative analysis of streptothricin hydrolysates. J Chromatogr. 1965 Jul;19(1):214–215. doi: 10.1016/s0021-9673(01)99452-x. [DOI] [PubMed] [Google Scholar]
- Tsuruoka T., Shomura T., Ezaki N., Niwa T., Niida T. SF-701, a new streptothricin-like antibiotic. J Antibiot (Tokyo) 1968 Mar;21(3):237–238. doi: 10.7164/antibiotics.21.237. [DOI] [PubMed] [Google Scholar]