Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1972 May;1(5):403–407. doi: 10.1128/aac.1.5.403

Analytical Method for Streptothricin-Type Antibiotics: Structure of Antibiotic LL-BL1361

D B Borders 1, J P Kirby 1, E R Wetzel 1, M C Davies 1,2, W K Hausmann 1,3
PMCID: PMC444232  PMID: 4670481

Abstract

An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N-methyl-desformimino derivative of antibiotic LL-AC541.

Full text

PDF
403

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borders D. B., Sax K. J., Lancaster J. E., Hausmann W. K., Mitscher L. A., Wetzel E. R., Patterson E. L. Structures of LL-AC541 and LL-AB664: new streptothricin-type antibiotics. Tetrahedron. 1970 Jul;26(13):3123–3133. doi: 10.1016/s0040-4020(01)92895-9. [DOI] [PubMed] [Google Scholar]
  2. Egorov G. A., Reshetov P. D., Khokhlov A. S. A method for the quantitative analysis of streptothricin hydrolysates. J Chromatogr. 1965 Jul;19(1):214–215. doi: 10.1016/s0021-9673(01)99452-x. [DOI] [PubMed] [Google Scholar]
  3. Tsuruoka T., Shomura T., Ezaki N., Niwa T., Niida T. SF-701, a new streptothricin-like antibiotic. J Antibiot (Tokyo) 1968 Mar;21(3):237–238. doi: 10.7164/antibiotics.21.237. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES