Abstract
Eighty per cent of mice infected with a mouse-adapted strain of influenza virus died within 3 to 8 days after infection. Rimantadine given at maximum protective doses reduced mortality to 10%. This protection is dose related and can be demonstrated with doses from 4.5 to 24 mg per kg per day. Significant survival rates are shown by delaying treatment as long as 48 hr after infection. Lungs of treated mice have significantly less virus than those of controls at 24, 48, and 72 hr after infection. Antibody production as measured by hemagglutination inhibition is not different in treated and controlled mice. These results indicate that rimantadine is an effective prophylactic and therapeutic agent and that its activity is associated with decreased viral titers.
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- DAVIES W. L., GRUNERT R. R., HAFF R. F., MCGAHEN J. W., NEUMAYER E. M., PAULSHOCK M., WATTS J. C., WOOD T. R., HERMANN E. C., HOFFMANN C. E. ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE). Science. 1964 May 15;144(3620):862–863. doi: 10.1126/science.144.3620.862. [DOI] [PubMed] [Google Scholar]
- Dawkins A. T., Jr, Gallager L. R., Togo Y., Hornick R. B., Harris B. A. Studies on induced influenza in man. II. Double-blind study designed to assess the prophylactic efficacy of an analogue of amantadine hydrochloride. JAMA. 1968 Mar 25;203(13):1095–1099. doi: 10.1001/jama.203.13.1095. [DOI] [PubMed] [Google Scholar]
- Falabella F. Bleeding mice: a successful technique of cardiac puncture. J Lab Clin Med. 1967 Dec;70(6):981–982. [PubMed] [Google Scholar]
- Francis T., Jr THE INACTIVATION OF EPIDEMIC INFLUENZA VIRUS BY NASAL SECRETIONS OF HUMAN INDIVIDUALS. Science. 1940 Feb 23;91(2356):198–199. doi: 10.1126/science.91.2356.198. [DOI] [PubMed] [Google Scholar]
- GRUNERT R. R., MCGAHEN J. W., DAVIES W. L. THE IN VIVO ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE). I. PROPHYLACTIC AND THERAPEUTIC ACTIVITY AGAINST INFLUENZA VIRUSES. Virology. 1965 Jun;26:262–269. doi: 10.1016/0042-6822(65)90273-4. [DOI] [PubMed] [Google Scholar]
- McGahen J. W., Hoffmann C. E. Influenza infections of mice. I. Curative activity of amantadine HCl. Proc Soc Exp Biol Med. 1968 Dec;129(3):678–681. doi: 10.3181/00379727-129-33395. [DOI] [PubMed] [Google Scholar]
- NEUMAYER E. M., HAFF R. F., HOFFMAN C. E. ANTIVIRAL ACTIVITY OF AMANTADINE HYDROCHLORIDE IN TISSUE CULTURE AND IN OVO. Proc Soc Exp Biol Med. 1965 Jun;119:393–396. doi: 10.3181/00379727-119-30191. [DOI] [PubMed] [Google Scholar]
- Rabinovich S., Baldini J. T., Bannister R. Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak. Am J Med Sci. 1969 May;257(5):328–335. doi: 10.1097/00000441-196905000-00005. [DOI] [PubMed] [Google Scholar]
- Togo Y., Hornick R. B., Dawkins A. T., Jr Studies on induced influenza in man. I. Double-blind studies designed to assess prophylactic efficacy of amantadine hydrochloride against a2/Rockville/1/65 strain. JAMA. 1968 Mar 25;203(13):1089–1094. doi: 10.1001/jama.203.13.1089. [DOI] [PubMed] [Google Scholar]