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. 1972 May;1(5):427–432. doi: 10.1128/aac.1.5.427

Reversibility of Protein Binding of Penicillins: an In Vitro Study Employing a Rapid Diafiltration Process

Michael Barza 1, Hugh Vine 1, Louis Weinstein 1
PMCID: PMC444237  PMID: 4670485

Abstract

The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature, pH, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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