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. 1972 Jun;1(6):483–488. doi: 10.1128/aac.1.6.483

Congocidine and Distamycin A, Antipoxvirus Antibiotics

Yechiel Becker 1, Yael Asher 1, Zichriya Zakay-Rones 1
PMCID: PMC444247  PMID: 4376908

Abstract

The antibiotics congocidine and distamycin A inhibited the replication of Shope fibroma and vaccinia viruses in BSC1 cells. Treatment of infected cultures with congocidine for a 12-hr period resulted in an irreversible inhibitory effect on virus development. A longer period of treatment with the antibiotic also resulted in inhibition of the residual infectious virions present in the treated cells. Distamycin A inhibited the replication of poxviruses, but its inhibitory effect was reversed when the antibiotic was removed from the infected cells even as long as 24 hr after treatment. The inhibitory effect of distamycin A and its reversibility resembled the antipoxvirus activity of rifampin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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