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. 1972 Jun;1(6):504–507. doi: 10.1128/aac.1.6.504

Comparative Clinical Pharmacology of Amoxicillin and Ampicillin Administered Orally

Ralph C Gordon 1, Claude Regamey 1, William M M Kirby 1
PMCID: PMC444250  PMID: 4680813

Abstract

Ampicillin and amoxicillin (α-amino-p-hydroxybenzyl penicillin) were administered orally in 500-mg doses to eight fasting volunteers in a comparative study in which pharmacokinetic techniques were used. The absorption of amoxicillin was significantly better, as demonstrated by a higher mean peak serum concentration of 7.6 μg/ml as compared to 3.2 μg/ml for ampicillin, an average “area under the curve” that was approximately double that of ampicillin, and an 8-hr urinary recovery for amoxicillin of 60% as compared to 34% for ampicillin. Serum half-lives were the same for the two antibiotics, with values of 60.3 (±3.3) min for ampicillin and 61.3 (±5.6) min for amoxicillin. The latter drug gave measurable concentrations in the blood at 8 hr in all of eight volunteers, as compared to only three of eight with ampicillin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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