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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neurotoxicology. 2015 Mar 14;48:100–108. doi: 10.1016/j.neuro.2015.03.007

Figure 4. Protection of C57BL/6 Mice from TMDT-induced Clonic Seizures.

Figure 4

Figure depicts seizures per mouse as a function of dose of the DZP:MK-801 combination treatment. Circles: DZP:MK-801 3:1 fixed ratio doses, and Solid line: Peak, log normal four parameter nonlinear regression of these points (r2 = 0.90). Diamond: A 3:1 dose (DZP:MK-801 1.2:0.4 mg/kg), where MK-801 was administered 10 min after DZP administration. This regimen provided a significantly greater suppression of clonic seizures (p= 0.018, Mann-Whitney U Test). Square: An 11:1 dose (DZP:MK-801 1.8:0.16 mg/kg) providing effective suppression of clonic seizures.