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. 1972 Sep;2(3):156–158. doi: 10.1128/aac.2.3.156

Effect of Ribosomal Wash Factors on Inhibition by Chloramphenicol

Helen J Cameron 1, Samuel J Rogers 1, Gordon R Julian 1
PMCID: PMC444283  PMID: 4597705

Abstract

In vitro protein-synthesizing systems from Escherichia coli can be categorized as either chloramphenicol-sensitive or chloramphenicol-insensitive. The chloramphenicol-sensitive systems used in this study required the presence of factors removed from ribosomes with 1.0 m NH4Cl when chromatographically purified ribosomes were used for amino acid incorporation. These ribosomal wash factors inhibited but did not eliminate amino acid incorporation in chloramphenicol-insensitive systems. For both systems, addition of increasing amounts of the ribosomal wash factors increased the sensitivity to chloramphenicol inhibition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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