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. 1972 Sep;2(3):214–216. doi: 10.1128/aac.2.3.214

Serum Protein Binding of the Aminoglycoside Antibiotics

Ralph C Gordon 1, Claude Regamey 1, William M M Kirby 1
PMCID: PMC444293  PMID: 4790560

Abstract

The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting studies are discussed, and some of the pharmacological implications are considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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