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. 1972 Oct;2(4):245–249. doi: 10.1128/aac.2.4.245

Susceptibility of Mycobacteria to Rifampin

Charles L Woodley 1, James O Kilburn 1, Hugo L David 1, Vella A Silcox 1
PMCID: PMC444300  PMID: 4670494

Abstract

The Mycobacterium species M. tuberculosis, M. avium-intracellulare, M. kansasii, M. marinum, M. scrofulaceum, M. fortuitum, M. terrae, and M. gordonae were analyzed for their susceptibility to rifampin. M. tuberculosis, M. kansasii, and M. marinum were susceptible to the antibiotic, and resistant populations developed as a result of the interplay of mutation and selection. The mutation rates (susceptibility → resistance) were calculated to be 4.9 × 10−10 and 1.7 × 10−9 mutations per bacterium per generation in, respectively, M. kansasii and M. marinum. M. fortuitum was found to be naturally resistant to the antibiotic, whereas the nature of resistance in the other species was unclear and is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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