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. 1972 Oct;2(4):287–290. doi: 10.1128/aac.2.4.287

Cephamycins, a New Family of β-Lactam Antibiotics. IV. In Vivo Studies1

A Kathrine Miller a, Evemarie Celozzi a, Yulin Kong a, Barbara A Pelak a, Helmut Kropp a, Edward O Stapley a, David Hendlin a
PMCID: PMC444308  PMID: 4670502

Abstract

Cephamycin A was found to be more active in vivo than cephamycin B. In comparison with cephamycin C, cephamycin A was more active against gram-positive organisms but less active against gram-negative organisms. Given subcutaneously, cephamycin C had good in vivo gram-negative activity, comparing favorably with cephalothin and cephaloridine against cephalosporin-susceptible organisms. In general, against the gram-negative organisms, it was more active than cephalothin or cephalosporin C and about as active as cephaloridine. In addition, cephamycin C protected mice against β-lactamase-producing Proteus cultures, including clinically isolated strains. The compound is remarkably nontoxic. Cephamycin C was detected in the serum and recovered from the urine of treated mice to about the same extent as cephaloridine. Like cephaloridine and cephalosporin C, cephamycin C must be excreted mainly by glomerular filtration, because the use of probenecid did not enhance the therapeutic effectiveness nor concentrations of these agents in the sera of treated mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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