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. 1972 Nov;2(5):373–383. doi: 10.1128/aac.2.5.373

Silver Sulfadiazine: Interaction with Isolated Deoxyribonucleic Acid

Herbert S Rosenkranz 1, Samuel Rosenkranz 1
PMCID: PMC444323  PMID: 4677596

Abstract

Silver sulfadiazine (AgSu) was found to interact with isolated deoxyribonucleic acid (DNA) to form nondissociable complexes. These complexes differ in physical and chemical properties from those that are established when silver nitrate is added to DNA. The reaction between AgSu and DNA is visualized as occurring in two stages: (i) a weak and reversible interaction (intercalation) between DNA and the sulfadiazine moiety and (ii) a tight binding involving the silver atom. In the first stage, sodium sulfadiazine competes with AgSu for the DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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