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. 1972 Dec;2(6):485–491. doi: 10.1128/aac.2.6.485

Inhibition of Peptidoglycan Synthesis by the Antibiotic Diumycin A

E J J Lugtenberg a,1, J A Hellings a, G J Van De Berg a
PMCID: PMC444343  PMID: 4670441

Abstract

Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus, a phenomenon accompanied by accumulation of uridine-5′-diphosphate-N-acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N-acetyl-glucosamine-N-acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d-alanine carboxypeptidase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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