Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1973 Jan;3(1):29–32. doi: 10.1128/aac.3.1.29

Poly(N-Acryloyl-4- and -5-Aminosalicylic Acids II. Antibacterial Properties and Uses for the Preparation of Active, Insoluble Antibiotics

J F Kennedy 1, J Epton 1, G R Kennedy 1
PMCID: PMC444356  PMID: 4790573

Abstract

The antibacterial properties of poly(N-acryloyl-4- and -5-aminosalicylic acids) and their borate complexes were evaluated. Poly(N-acryloyl-4- and 5-aminosalicylic acids) were used to render the antibiotics streptomycin and gentamicin insoluble. The antibacterial properties of the resultant water-insoluble streptomycin and gentamicin derivatives were evaluated, and the results show that the polymers are suited to the preparation of active insoluble antibiotics. Potential antimicrobial applications of the polymers are discussed.

Full text

PDF
29

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Rinderknecht H., Ward J. L., Bergel F., Morrison A. L. Studies on antibiotics: 2. Bacteriological activity and possible mode of action of certain non-nitrogenous natural and synthetic antibiotics. Biochem J. 1947;41(3):463–469. doi: 10.1042/bj0410463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Scudi J. V., Boxer G. E., Jelinek V. C. A Color Reaction Given by Streptomycin. Science. 1946 Nov 22;104(2708):486–487. doi: 10.1126/science.104.2708.486. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES