Abstract
Chloramphenicol acetyltransferases specified by fi− (F fertility-noninhibiting) R factors were compared with those specified by the fi+ R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi− R factors and was indistinguishable from the enzyme determined by fi+ R factors, class II was correlated with group W fi− R factors, and class III was determined by R387, an unclassified fi− R factor.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aoki T., Egusa S., Ogata Y., Watanabe T. Detection of resistance factors in fish pathogen Aeromonas liquefaciens. J Gen Microbiol. 1971 Mar;65(3):343–349. doi: 10.1099/00221287-65-3-343. [DOI] [PubMed] [Google Scholar]
- Datta N., Hedges R. W. Compatibility groups among fi - R factors. Nature. 1971 Nov 26;234(5326):222–223. doi: 10.1038/234222a0. [DOI] [PubMed] [Google Scholar]
- Datta N., Hedges R. W., Shaw E. J., Sykes R. B., Richmond M. H. Properties of an R factor from Pseudomonas aeruginosa. J Bacteriol. 1971 Dec;108(3):1244–1249. doi: 10.1128/jb.108.3.1244-1249.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Foster T. J., Howe T. G. Chloramphenicol acetyl transferase formed by wild-type and complementing R factors in Escherichia coli K12. J Gen Microbiol. 1972 Aug;71(3):575–580. doi: 10.1099/00221287-71-3-575. [DOI] [PubMed] [Google Scholar]
- Foster T. J., Howe T. G. Recombination and complementation between R factors in Escheichia coli K 12. Genet Res. 1971 Dec;18(3):287–297. doi: 10.1017/s0016672300012696. [DOI] [PubMed] [Google Scholar]
- Hedges R. W., Datta N. R124, an fi R factor of a new compatibility class. J Gen Microbiol. 1972 Jul;71(2):403–405. doi: 10.1099/00221287-71-2-403. [DOI] [PubMed] [Google Scholar]
- Jack G. W., Richmond M. H. A comparative study of eight distinct beta-lactamases synthesized by gram-negative bacteria. J Gen Microbiol. 1970 Apr;61(1):43–61. doi: 10.1099/00221287-61-1-43. [DOI] [PubMed] [Google Scholar]
- Meynell E., Datta N. The relation of resistance transfer factors to the F-factor (sex-factor) of Escherichia coli K12. Genet Res. 1966 Feb;7(1):134–140. doi: 10.1017/s0016672300009538. [DOI] [PubMed] [Google Scholar]
- Nagai Y., Mitsuhashi S. New type of R factors incapable of inactivating chloramphenicol. J Bacteriol. 1972 Jan;109(1):1–7. doi: 10.1128/jb.109.1.1-7.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaw W. V., Brodsky R. F. Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus. J Bacteriol. 1968 Jan;95(1):28–36. doi: 10.1128/jb.95.1.28-36.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaw W. V., Brodsky R. F. Chloramphenicol resistance by enzymatic acetylation: comparative aspects. Antimicrob Agents Chemother (Bethesda) 1967;7:257–263. [PubMed] [Google Scholar]
- Shaw W. V. Enzymatic chlorampheicol acetylation and R factor induced antibiotic resistance in Enterobacteriaceae. Antimicrob Agents Chemother (Bethesda) 1966;6:221–226. [PubMed] [Google Scholar]
- Shaw W. V., Sands L. C., Datta N. Hybridization of variants of chloramphenicol acetyltransferase specified by fi + and fi - R factors. Proc Natl Acad Sci U S A. 1972 Oct;69(10):3049–3053. doi: 10.1073/pnas.69.10.3049. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shaw W. V. The enzymatic acetylation of chloramphenicol by extracts of R factor-resistant Escherichia coli. J Biol Chem. 1967 Feb 25;242(4):687–693. [PubMed] [Google Scholar]
- Shaw W. V. The problems of drug-resistant pathogenic bacteria. Comparative enzymology of chloramphenicol resistance. Ann N Y Acad Sci. 1971 Jun 11;182:234–242. doi: 10.1111/j.1749-6632.1971.tb30660.x. [DOI] [PubMed] [Google Scholar]
- Suzuki Y., Okamoto S. The enzymatic acetylation of chloramphenicol by the multiple drug-resistant Escherichia coli carrying R factor. J Biol Chem. 1967 Oct 25;242(20):4722–4730. [PubMed] [Google Scholar]
- WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation. J Bacteriol. 1961 May;81:669–678. doi: 10.1128/jb.81.5.669-678.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., LYANG K. W. Episome-mediated transfer of drug resistance in Enterobacteriaceae. V. Spontaneous segregation and recombination of resistance factors in Salmonella typhimurium. J Bacteriol. 1962 Sep;84:422–430. doi: 10.1128/jb.84.3.422-430.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., NISHIDA H., OGATA C., ARAI T., SATO S. EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. VII. TWO TYPES OF NATURALLY OCCURRING R FACTORS. J Bacteriol. 1964 Sep;88:716–726. doi: 10.1128/jb.88.3.716-726.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE T., OGATA C., SATO S. EPISOME-MEDIATED TRANSFER OF DRUG RESISTANCE IN ENTEROBACTERIACEAE. 8. SIX-DRUG-RESISTANCE R FACTOR. J Bacteriol. 1964 Oct;88:922–928. doi: 10.1128/jb.88.4.922-928.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watanabe T., Furuse C., Sakaizumi S. Transduction of various R factors by phage P1 in Escherichia coli and by phage P22 in Salmonella typhimurium. J Bacteriol. 1968 Nov;96(5):1791–1795. doi: 10.1128/jb.96.5.1791-1795.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]