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. 1973 Feb;3(2):198–206. doi: 10.1128/aac.3.2.198

Studies on the Toxicity and Antiviral Activity of Various Polynucleotides1

D R Black 1,2,2, F Eckstein 1,2, E DeClercq 1,2,3, T C Merigan 1,2
PMCID: PMC444387  PMID: 4790587

Abstract

Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in toxicity. This was reflected by a fivefold range in therapeutic ratio for the various compounds. In addition, no polynucleotide proved to be a more potent interferon inducer than polyinosinic·polycytidylic acid [(poly rI)·(poly rC)]. Our results suggest that there may be intrinsic limitations to the development of polynucleotide interferon inducers having improved therapeutic ratios.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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