Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1973 Feb;3(2):262–265. doi: 10.1128/aac.3.2.262

Amoxicillin, a New Penicillin Antibiotic

H Hunter Handsfield 1, Hugh Clark 1, James F Wallace 1, King K Holmes 1, Marvin Turck 1
PMCID: PMC444397  PMID: 4208282

Abstract

Amoxicillin (α-amino-p-hydroxybenzyl penicillin, BRL 2333) is a new semisynthetic penicillin which is structurally similar to ampicillin, but which is better absorbed and yields higher concentrations in serum and urine. The in vitro susceptibility of 145 strains of Enterobacteriaceae and 30 isolates of Pseudomonas aeruginosa was determined against various concentrations of amoxicillin and ampicillin in agar. In addition, inhibitory zones around discs containing 10 μg of amoxicillin were measured and compared with results of agar dilution studies. The drug also was evaluated in the treatment of 38 patients with bacteriuria, who received doses of either 750 mg or 1 g/day for 10 days. In vitro, amoxicillin was comparable in activity to ampicillin; most isolates of Escherichia coli and Proteus mirabilis were inhibited by 10 μg or less/ml, whereas the majority of strains of Enterobacter, Klebsiella, indole-positive Proteus species, and Pseudomonas grew in concentrations greater than 50 μg/ml. Clinically, amoxicillin was effective in eradicating bacteriuria due to susceptible organisms and was very well tolerated. For practical purposes, however, amoxicillin performed no better than a host of other drugs presently available for the treatment of acute, uncomplicated bacteriuria.

Full text

PDF
262

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON K. N., KENNEDY R. P., PLORDE J. J., SHULMAN J. A., PETERSDORF R. G. EFFECTIVENESS OF AMPICILLIN AGAINST GRAM-NEGATIVE BACTERIA. IN VITRO AND IN VIVO STUDIES OF A NEW ANTIBIOTIC. JAMA. 1964 Feb 22;187:555–561. [PubMed] [Google Scholar]
  2. Acred P., Hunter P. A., Mizen L., Rolinson G. N. -amino-p-hydroxybenzylpenicillin (BRL 2333), a new broad-spectrum semisynthetic penicillin: in vivo evaluation. Antimicrob Agents Chemother (Bethesda) 1970;10:416–422. [PubMed] [Google Scholar]
  3. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  4. Croydon E. A., Sutherland R. -amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: absorption and excretion in man. Antimicrob Agents Chemother (Bethesda) 1970;10:427–430. [PubMed] [Google Scholar]
  5. LINDEMEYER R. I., TURCK M., PETERSDORF R. G. Factors determining the outcome of chemotherapy in infections of the urinary tract. Ann Intern Med. 1963 Feb;58:201–216. doi: 10.7326/0003-4819-58-2-201. [DOI] [PubMed] [Google Scholar]
  6. Neu H. C., Winshell E. B. In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin. Antimicrob Agents Chemother (Bethesda) 1970;10:407–410. [PubMed] [Google Scholar]
  7. Neu H. C., Winshell E. B. Pharmacological studies of 6 (D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid in humans. Antimicrob Agents Chemother (Bethesda) 1970;10:423–426. [PubMed] [Google Scholar]
  8. Ronald A. R., Turck M., Petersdorf R. G. A critical evaluation of nalidixic acid in urinary-tract infections. N Engl J Med. 1966 Nov 17;275(20):1081–1089. doi: 10.1056/NEJM196611172752001. [DOI] [PubMed] [Google Scholar]
  9. Sutherland R., Rolinson G. N. -amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: in vitro evaluation. Antimicrob Agents Chemother (Bethesda) 1970;10:411–415. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES