Abstract
The fungus Alternaria tenuis normally produces tenuazonic acid (3-acetyl-5-secbutyltetramic acid). On supplementation of the culture substrate with l-valine and l-leucine, the organism formed two new tetramic acids, 3-acetyl-5-isopropyltetramic acid and 3-acetyl-5-isobutyltetramic acid, respectively. l-Phenylalanine was not utilized by the organism as a tetramic acid precursor.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gitterman C. O. Antitumor, cytotoxic, and antibacterial activities of tenuazonic acid and congeneric tetramic acids. J Med Chem. 1965 Jul;8(4):483–486. doi: 10.1021/jm00328a015. [DOI] [PubMed] [Google Scholar]
- Harris S. A., Fisher L. V., Folkers K. The synthesis of tenuazonic and congeneric tetramie acids. J Med Chem. 1965 Jul;8(4):478–482. doi: 10.1021/jm00328a014. [DOI] [PubMed] [Google Scholar]
- ROSETT T., SANKHALA R. H., STICKINGS C. E., TAYLOR M. E., THOMAS R. Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis auct; culture filtrate products. Biochem J. 1957 Nov;67(3):390–400. doi: 10.1042/bj0670390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHIGEURA H. T., GORDON C. N. THE BIOLOGICAL ACTIVITY OF TENUAZONIC ACID. Biochemistry. 1963 Sep-Oct;2:1132–1137. doi: 10.1021/bi00905a039. [DOI] [PubMed] [Google Scholar]
- STICKINGS C. E. Studies in the biochemistry of micro-organisms. 106. Metabolites of Alternaria tenuis auct.: the structure of tenuazonic acid. Biochem J. 1959 Jun;72(2):332–340. doi: 10.1042/bj0720332. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stickings C. E., Townsend R. J. Studies in the biochemistry of micro-organisms. 108. Metabolites of Alternaria tenuis Auct.: the biosynthesis of tenuazonic acid. Biochem J. 1961 Feb;78(2):412–418. doi: 10.1042/bj0780412. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yuki H., Tohira Y., Aoki B., Kano T., Takama S. Studies on antiviral agents. 3. Synthesis of tenuazonic acid derivatives. Chem Pharm Bull (Tokyo) 1967 Aug;15(8):1107–1111. doi: 10.1248/cpb.15.1107. [DOI] [PubMed] [Google Scholar]