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. 1973 Mar;3(3):425–431. doi: 10.1128/aac.3.3.425

U-42, 126, a New Antimetabolite Antibiotic: Production, Biological Activity, and Taxonomy of the Producing Microorganism

L J Haňka 1, A Dietz 1
PMCID: PMC444426  PMID: 4790601

Abstract

A new antimetabolite antibiotic, U-42,126, was discovered by use of a specific in vitro screen. U-42,126 was produced by the fermentation of Streptomyces sviceus. Its antimicrobial activity in vitro was limited to fungi. Certain bacteria were inhibited only when cultivated in completely synthetic media. U-42,126 was active in vivo against L1210 leukemia in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DIETZ A. Ektachrome transparencies as aids in actinomycete classification. Ann N Y Acad Sci. 1954 Oct 29;60(1):152–154. doi: 10.1111/j.1749-6632.1954.tb40004.x. [DOI] [PubMed] [Google Scholar]
  2. Dietz A., Mathews J. Classification of Streptomyces spore surfaces into five groups. Appl Microbiol. 1971 Mar;21(3):527–533. doi: 10.1128/am.21.3.527-533.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dietz A. Streptomyces steffisburgensis sp.n. J Bacteriol. 1967 Dec;94(6):2022–2026. doi: 10.1128/jb.94.6.2022-2026.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hanka L. J., Bergy M. E., Kelly R. B. Naturally occurring antimetabolite antibiotic related to biotin. Science. 1966 Dec 30;154(3757):1667–1668. doi: 10.1126/science.154.3757.1667. [DOI] [PubMed] [Google Scholar]
  5. Hanka L. J., Evans J. S., Mason D. J., Dietz A. Microbiological production of 5-azacytidine. I. Production and biological activity. Antimicrob Agents Chemother (Bethesda) 1966;6:619–624. [PubMed] [Google Scholar]
  6. Hanka L. J., Martin D. G., Reineke L. M. Two new antimetabolites of biotin: alpha-methyldethiobiotin and alpha-methylbiotin. Antimicrob Agents Chemother. 1972 Feb;1(2):135–138. doi: 10.1128/aac.1.2.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Korobkova T. P., Maximova T. S., Kovsharova I. N., Terekhova L. P. Obrazovanie aktinomitsetami antibiotikov-antimetabolitov riada aminokislot i vitaminov. Antibiotiki. 1971 Jan;16(1):36–39. [PubMed] [Google Scholar]
  8. PRIDHAM T. G., HESSELTINE C. W., BENEDICT R. G. A guide for the classification of streptomycetes according to selected groups; placement of strains in morphological sections. Appl Microbiol. 1958 Jan;6(1):52–79. doi: 10.1128/am.6.1.52-79.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pridham T. G., Gottlieb D. The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species Determination. J Bacteriol. 1948 Jul;56(1):107–114. doi: 10.1128/jb.56.1.107-114.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. TRESNER H. D., BACKUS E. J. System of color wheels for streptomycete taxonomy. Appl Microbiol. 1963 Jul;11:335–338. doi: 10.1128/am.11.4.335-338.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]

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