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. 1973 Apr;3(4):498–502. doi: 10.1128/aac.3.4.498

N,N-Dioctadecyl-N′,N′-Bis(2-Hydroxyethyl) Propanediamine: Antiviral Activity and Interferon Stimulation in Mice

W W Hoffman 1, J J Korst 1, J F Niblack 1, T H Cronin 1
PMCID: PMC444441  PMID: 4364178

Abstract

CP-20,961, N,N-dioctadecyl-N′, N′-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. Parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and Semliki Forest viruses and effectively suppressed pox formation by vaccinia infection. Maximal antiviral effects were observed when CP-20,961 was administered 6 to 12 h before infection. An interferon detected in plasma 12 to 20 h after the drug was given appeared to mediate these effects. Comparison of the minimal effective and lethal doses in mice established a therapeutic index of 300.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Absher M., Stinebring W. R. Toxic properties of a synthetic double-stranded RNA. Endotoxin-like properties of poly I. poly C, an interferon stimulator. Nature. 1969 Aug 16;223(5207):715–717. doi: 10.1038/223715a0. [DOI] [PubMed] [Google Scholar]
  2. Azuma M., Yamada M., Nishioka R. Relationship between immunity and interferon production in macrophages. II. Molecular weights of interferon produced in macrophage cultures. Jpn J Microbiol. 1970 Jul;14(4):319–323. doi: 10.1111/j.1348-0421.1970.tb00530.x. [DOI] [PubMed] [Google Scholar]
  3. Boyle J. J., Haff R. F., Stewart R. C. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob Agents Chemother (Bethesda) 1966;6:536–539. [PubMed] [Google Scholar]
  4. De Clercq E., Merigan T. C. Bis-DEAE-fluorenone: mechanism of antiviral protection and stimulation of interferon production in the mouse. J Infect Dis. 1971 Feb;123(2):190–199. doi: 10.1093/infdis/123.2.190. [DOI] [PubMed] [Google Scholar]
  5. De Clercq E., Merigan T. C. Induction of interferon by nonviral agents. Arch Intern Med. 1970 Jul;126(1):94–108. doi: 10.1001/archinte.126.1.94. [DOI] [PubMed] [Google Scholar]
  6. De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. J Virol. 1968 Sep;2(9):886–893. doi: 10.1128/jvi.2.9.886-893.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hilleman M. R. Double-stranded RNAs (poly I:C) in the prevention of viral infections. Arch Intern Med. 1970 Jul;126(1):109–124. [PubMed] [Google Scholar]
  8. Joshi N. N., Jones M., McColl J. D. Quantitation of tail lesions in vaccinia-infected mice. Appl Microbiol. 1969 Nov;18(5):935–935. doi: 10.1128/am.18.5.935-935.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lampson G. P., Tytell A. A., Field A. K., Nemes M. M., Hilleman M. R. Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):782–789. doi: 10.1073/pnas.58.2.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mayer G. D., Krueger R. F. Tilorone hydrochloride: mode of action. Science. 1970 Sep 18;169(3951):1214–1215. doi: 10.1126/science.169.3951.1214. [DOI] [PubMed] [Google Scholar]
  11. Merigan T. C. Induction of circulating interferon by synthetic anionic polymers of known composition. Nature. 1967 Apr 22;214(5086):416–417. doi: 10.1038/214416a0. [DOI] [PubMed] [Google Scholar]
  12. SENIOR J. R. INTESTINAL ABSORPTION OF FATS. J Lipid Res. 1964 Oct;5:495–521. [PubMed] [Google Scholar]
  13. Smith T. J., Wagner R. R. Rabbit macrophage interferons. II. Some physicochemical properties and estimations of molecular weights. J Exp Med. 1967 Apr 1;125(4):579–593. doi: 10.1084/jem.125.4.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wheelock E. F. Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science. 1965 Jul 16;149(3681):310–311. [PubMed] [Google Scholar]
  15. Youngner J. S., Stinebring W. R., Taube S. E. Influence of inhibitors of protein synthesis on interferon formation in mice. Virology. 1965 Dec;27(4):541–550. doi: 10.1016/0042-6822(65)90179-0. [DOI] [PubMed] [Google Scholar]

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