Table 1, “Percentage injury at p18 and p30”, incorrectly appears twice. Please see the corrected Table 1 here.
Table 1. Percentage injury at p18 and p30.
| Sex | Region | Treatment Group | Median % Injury at p18 (Interquartile Range) | Significance (p) | Median % Injury at p30 (Interquartile Range) | Significance (p) |
|---|---|---|---|---|---|---|
| Male | Hippocampus | Control | 7.10 (0.67–11.44) | p < 0.001* | 1.09 (-0.89–6.17) | p < 0.001* |
| Normothermia | 73.33 (54.02–85.5) | — | 67.07 (44.69–84.67) | — | ||
| Hypothermia | 14.6 (9.53–28.91) | p < 0.001* | 29.99 (18.57–51.17) | p = 0.01*, p = 0.002† | ||
| Cortex | Control | 7.93 (3.68–11.01) | p = 0.001* | 4.07 (2.38–6.49) | p = 0.008 * | |
| Normothermia | 37.04 (24.67–53.59) | — | 28.29 (15.34–43.72) | — | ||
| Hypothermia | 8.8 (4.09–14.9) | p = 0.001* | 8.85 (2.21–23.6) | p = 0.05* | ||
| Striatum | Control | 3.56 (0.43–8.16) | p = 0.003* | 2.02 (-1.19–7.35) | p = 0.04* | |
| Normothermia | 34.84 (18.93–43.79) | — | 20.62 (3.4–50.12) | — | ||
| Hypothermia | 14.46 (7.3–27.89) | p = 0.04* | 18.11 (9.79–30.66) | — | ||
| Thalamus | Control | 0.00 (-0.21–0.47) | p = 0.002* | 0 (-0.14–0.61) | p < 0.001* | |
| Normothermia | 7.13 (4.83–12.33) | — | 15.65 (5.19–20.68) | — | ||
| Hypothermia | 3.01 (-0.4–8.31) | p = 0.04* | 7.25 (5.09–8.6) | p = 0.04*, p = 0.02† | ||
| Female | Hippocampus | Control | 3.23 (0.3–5.05) | p = 0.04* | 0 (-10.56–26.15) | p = 0.03* |
| Normothermia | 71.91 (15.8–96.92) | — | 51.4 (33.72–70.55) | — | ||
| Hypothermia | 55.72 (23.35–81.08) | p = 0.06* | 70.12 (48.9–81.82) | p = 0.005† | ||
| Cortex | Control | 8.31 (1.81–13.3) | p = 0.19‡ | 4.86 (0.76–6.8) | p = 0.07‡ | |
| Normothermia | 36.72 (9.8–53.19) | — | 20.03 (10.4–35.49) | — | ||
| Hypothermia | 25.41 (3.06–47.6) | — | 31.1 (18.53–50.65) | — | ||
| Striatum | Control | 0.26 (-3.05–7.66) | p = 0.04* | 0 (-1.18–2.51) | p = 0.02* | |
| Normothermia | 41.76 (20.59–56.19) | — | 23.57 (14.29–40.18) | — | ||
| Hypothermia | 25.16 (7.29–43.57) | — | 33.22 (16.67–51.02) | p = 0.01† | ||
| Thalamus | Control | 2.15 (-0.66–7.02) | p = 0.09‡ | 0.94 (-0.7–3.9) | — | |
| Normothermia | 10.74 (5.28–22.4) | — | 7.47 (3.64–10.9) | — | ||
| Hypothermia | 7.02 (4.63–10.75) | — | 7.05 (4.02–16.26) | p = 0.02† |
* = vs. NT
† = vs. ctrl
‡ = between groups
Reference
- 1. Burnsed JC, Chavez-Valdez R, Hossain MS, Kesavan K, Martin LJ, Zhang J, et al. (2015) Hypoxia-Ischemia and Therapeutic Hypothermia in the Neonatal Mouse Brain—A Longitudinal Study. PLoS ONE 10(3): e0118889 doi:10.1371/journal.pone.0118889 [DOI] [PMC free article] [PubMed] [Google Scholar]