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. 1973 Apr;3(4):526–529. doi: 10.1128/aac.3.4.526

Penicillin-Tobramycin Synergism Against Enterococci: a Comparison with Penicillin and Gentamicin

Robert C Moellering Jr 1, Christine Wennersten 1, Allan J Weinstein 1
PMCID: PMC444447  PMID: 4208292

Abstract

Combinations of penicillin plus tobramycin have been compared with penicillin plus gentamicin against 27 strains of enterococci isolated from blood cultures. Penicillin plus gentamicin was synergistic against all strains. The combination of penicillin plus tobramycin was equally effective against strains of Streptococcus facalis, but was ineffective against all four strains of S. faecium tested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black H. R., Griffith R. S. Preliminary studies with nebramycin factor 6. Antimicrob Agents Chemother (Bethesda) 1970;10:314–321. [PubMed] [Google Scholar]
  2. DEIBEL R. H. THE GROUP D STREPTOCOCCI. Bacteriol Rev. 1964 Sep;28:330–366. doi: 10.1128/br.28.3.330-366.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Facklam R. R. Recognition of group D streptococcal species of human origin by biochemical and physiological tests. Appl Microbiol. 1972 Jun;23(6):1131–1139. doi: 10.1128/am.23.6.1131-1139.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Koch K. F., Rhoades J. A. Structure of nebramycin factor 6, a new aminoglycosidic antibiotic. Antimicrob Agents Chemother (Bethesda) 1970;10:309–313. [PubMed] [Google Scholar]
  5. Mandell G. L., Kaye D., Levison M. E., Hook E. W. Enterococcal endocarditis. An analysis of 38 patients observed at the New York Hospital-Cornell Medical Center. Arch Intern Med. 1970 Feb;125(2):258–264. doi: 10.1001/archinte.125.2.258. [DOI] [PubMed] [Google Scholar]
  6. Moellering R. C., Jr, Wennersten C., Medrek T., Weinberg A. N. Prevalence of high-level resistance to aminoglycosides in clinical isolates of enterococci. Antimicrob Agents Chemother (Bethesda) 1970;10:335–340. [PubMed] [Google Scholar]
  7. Moellering R. C., Jr, Wennersten C., Weinberg A. N. Studies on antibiotic synergism against enterococci. I. Bacteriologic studies. J Lab Clin Med. 1971 May;77(5):821–828. [PubMed] [Google Scholar]
  8. Moellering R. C., Jr, Wennersten C., Weinberg A. N. Synergy of penicillin and gentamicin against Enterococci. J Infect Dis. 1971 Dec;124 (Suppl):S207–S209. doi: 10.1093/infdis/124.supplement_1.s207. [DOI] [PubMed] [Google Scholar]
  9. RANTZ L. A., RANDALL E. Use of autoclaved extracts of hemolytic streptococci for serological grouping. Stanford Med Bull. 1955 May;13(2):290–291. [PubMed] [Google Scholar]
  10. Shadomy S., Kirchoff C. In vitro susceptibility testing with tobramycin. Antimicrob Agents Chemother. 1972 May;1(5):412–416. doi: 10.1128/aac.1.5.412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Standiford H. D., De Maine J. B., Kirby W. M. Antibiotic synergism of enterococci. Relation to inhibitory concentrations. Arch Intern Med. 1970 Aug;126(2):255–259. [PubMed] [Google Scholar]
  12. Watanakunakorn C. Penicillin combined with gentamicin or streptomycin: synergism against enterococci. J Infect Dis. 1971 Dec;124(6):581–586. doi: 10.1093/infdis/124.6.581. [DOI] [PubMed] [Google Scholar]
  13. Zimmermann R. A., Moellering R. C., Jr, Weinberg A. N. Mechanism of resistance to antibiotic synergism in enterococci. J Bacteriol. 1971 Mar;105(3):873–879. doi: 10.1128/jb.105.3.873-879.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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