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. 1973 May;3(5):621–624. doi: 10.1128/aac.3.5.621

Silver Sulfadiazine: Effect on the Ultrastructure of Pseudomonas aeruginosa

Joe E Coward 1, Howard S Carr 1, Herbert S Rosenkranz 1
PMCID: PMC444467  PMID: 4208294

Abstract

Pseudomonas aeruginosa exposed to silver sulfadiazine (AgSu) were examined in an electron microscope. The treated cells were distorted in shape, and structures (blebs) protruded from the cell surface. These “blebs” appeared to arise from the cell wall. A strain of P. aeruginosa resistant to AgSu did not display these changes. Upon exposure of P. aeruginosa to silver nitrate, none of these changes was seen; rather, such cells are characterized by large, central aggregations of nuclear material. The results are consistent with previous findings which suggested that AgSu acted at the cell surface.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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