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. 1973 Jun;3(6):662–664. doi: 10.1128/aac.3.6.662

Uptake of Minocycline and Tetracycline by Tetracycline-Susceptible and -Resistant Bacteria

N A Kuck 1, M Forbes 1
PMCID: PMC444476  PMID: 4597735

Abstract

Minocycline (7-dimethylamino-6-demethyl-6-deoxytetracycline) is a new semisynthetic tetracycline with potent activity against tetracycline-susceptible bacterial pathogens and unique activity against tetracycline-resistant staphylococci. Studies to determine the basis for this unique activity showed that, whereas tetracycline-resistant staphylococci took up less 3H-tetracycline than the susceptible cells, both the tetracycline-resistant and -susceptible cells accumulated equivalent amounts of 14C-minocycline. In contrast, tetracycline-resistant Escherichia coli cells were relatively resistant to minocycline and accumulated less of both drugs than did the susceptible organisms. It is proposed that minocycline is effective against tetracycline-resistant staphylococci because of its ability to penetrate the cells sufficiently to reach inhibiting concentrations at sensitive reaction sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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