Abstract
BL-20803 induced interferon in mice when administered via oral or parenteral routes. During multiple dosing with the drug at 48-h intervals, animals exhibited a hyporesponsive state to the third treatment. Inhibition of vaccinia virus infection was correlated with interferon induction.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARON S., BUCKLER C. E. CIRCULATING INTERFERON IN MICE AFTER INTRAVENOUS INJECTION OF VIRUS. Science. 1963 Sep 13;141(3585):1061–1063. doi: 10.1126/science.141.3585.1061. [DOI] [PubMed] [Google Scholar]
- Borden E. C., Murphy F. A. The interferon refractory state: in vivo and in vitro studies of its mechanism. J Immunol. 1971 Jan;106(1):134–142. [PubMed] [Google Scholar]
- Boyle J. J., Haff R. F., Stewart R. C. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob Agents Chemother (Bethesda) 1966;6:536–539. [PubMed] [Google Scholar]
- Buckler C. E., DuBuy H. G., Johnson M. L., Baron S. Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C. Proc Soc Exp Biol Med. 1971 Feb;136(2):394–398. doi: 10.3181/00379727-136-35272. [DOI] [PubMed] [Google Scholar]
- Mayer G. D., Krueger R. F. Tilorone hydrochloride: mode of action. Science. 1970 Sep 18;169(3951):1214–1215. doi: 10.1126/science.169.3951.1214. [DOI] [PubMed] [Google Scholar]
- Stein R. G., Biel J. H., Singh T. Antimalarials. 4-Substituted 1H-pyrazolo[3,4-b]quinolines. J Med Chem. 1970 Jan;13(1):153–155. doi: 10.1021/jm00295a049. [DOI] [PubMed] [Google Scholar]