Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1973 Sep;4(3):248–253. doi: 10.1128/aac.4.3.248

Transmissible Resistance to Penicillin G, Neomycin, and Chloramphenicol in Rhizobium japonicum1

Michael A Cole a,2, Gerald H Elkan a
PMCID: PMC444536  PMID: 4491197

Abstract

The genetic basis for resistance to a number of antibiotics was examined in Rhizobium japonicum. Resistance to penicillin G, neomycin, and chloramphenicol appears to be mediated by an extrachromosomal element similar to that found in the Enterobacteriaceae. Resistance to these antibiotics was eliminated from cells by treatment with acridine orange, and resistance to all three antibiotics could be transferred en bloc to Agrobacterium tumefaciens under conditions excluding transformation or transduction as possible genetic mechanisms.

Full text

PDF
248

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. S., Lewis M. J. Characterization of a transfer factor associated with drug resistance in Salmonella typhimurium. Nature. 1965 Nov 27;208(5013):843–849. doi: 10.1038/208843a0. [DOI] [PubMed] [Google Scholar]
  2. Balassa G. GENETIC TRANSFORMATION OF RHIZOBIUM: A REVIEW OF THE WORK OF R. BALASSA. Bacteriol Rev. 1963 Jun;27(2):228–241. doi: 10.1128/br.27.2.228-241.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cohen S. N., Miller C. A. Non-chromosomal antibiotic resistance in bacteria. 3. Isolation of the discrete transfer unit of the R-factor R1. Proc Natl Acad Sci U S A. 1970 Oct;67(2):510–516. doi: 10.1073/pnas.67.2.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Elkan G. H., Kwik I. Nitrogen, energy and vitamin nutrition of Rhizobium japonicum. J Appl Bacteriol. 1968 Dec;31(4):399–404. doi: 10.1111/j.1365-2672.1968.tb00386.x. [DOI] [PubMed] [Google Scholar]
  5. Gadre S. V., Mazumdar L., Modi V. V., Parekh V. Interspecific transformation in Rhizobium. Arch Mikrobiol. 1967 Jul 6;57(4):388–391. doi: 10.1007/BF00416937. [DOI] [PubMed] [Google Scholar]
  6. Lindberg M., Sjöström J. E., Johansson T. Transformation of chromosomal and plasmid characters in Staphylococcus aureus. J Bacteriol. 1972 Feb;109(2):844–847. doi: 10.1128/jb.109.2.844-847.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Novick R. P., Roth C. Plasmid-linked resistance to inorganic salts in Staphylococcus aureus. J Bacteriol. 1968 Apr;95(4):1335–1342. doi: 10.1128/jb.95.4.1335-1342.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. RICHMOND M. H., JOHN M. CO-TRANSDUCTION BY A STAPHYLOCOCCAL PHAGE OF THE GENES RESPONSIBLE FOR PENICILLINASE SYNTHESIS AND RESISTANCE TO MERCURY SALTS. Nature. 1964 Jun 27;202:1360–1361. doi: 10.1038/2021360a0. [DOI] [PubMed] [Google Scholar]
  9. ROSLYCKY E. B., ALLEN O. N., McCOY E. Phages for Agrobacterium radiobacter with reference to host range. Can J Microbiol. 1962 Feb;8:71–78. doi: 10.1139/m62-010. [DOI] [PubMed] [Google Scholar]
  10. SZYBALSKI W., BRYSON V. Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibiotics. J Bacteriol. 1952 Oct;64(4):489–499. doi: 10.1128/jb.64.4.489-499.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. I. Transfer of resistance factors by conjugation. J Bacteriol. 1961 May;81:669–678. doi: 10.1128/jb.81.5.669-678.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae. II. Elimination of resistance factors with acridine dyes. J Bacteriol. 1961 May;81:679–683. doi: 10.1128/jb.81.5.679-683.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WATANABE T. Infective heredity of multiple drug resistance in bacteria. Bacteriol Rev. 1963 Mar;27:87–115. doi: 10.1128/br.27.1.87-115.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES