Abstract
The incidence of lactose-fermenting enteric organisms resistant to chloramphenicol increased from less than 0.1% prior to treatment to more than 90% in two groups of chickens fed racephenicol-supplemented feed at 50 or 140 g/ton for 10 days, whereas controls remained unchanged. A concurrent increase in the incidence of organisms resistant to dihydrostreptomycin, oxytetracycline, ampicillin, and sulfonamides also occurred. Minimum inhibitory concentrations for chloramphenicol increased from <10 μg/ml to >300 μg/ml in most Escherichia coli isolates in response to treatment. The observed resistance was transferable to E. coli and Salmonella.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson E. S. The ecology of transferable drug resistance in the enterobacteria. Annu Rev Microbiol. 1968;22:131–180. doi: 10.1146/annurev.mi.22.100168.001023. [DOI] [PubMed] [Google Scholar]
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Datta N. Infectious drug resistance. Br Med Bull. 1965 Sep;21(3):254–259. doi: 10.1093/oxfordjournals.bmb.a070405. [DOI] [PubMed] [Google Scholar]
- MacLowry J. D., Jaqua M. J., Selepak S. T. Detailed methodology and implementation of a semiautomated serial dilution microtechnique for antimicrobial susceptibility testing. Appl Microbiol. 1970 Jul;20(1):46–53. doi: 10.1128/am.20.1.46-53.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mercer H. D., Pocurull D., Gaines S., Wilson S., Bennett J. V. Characteristics of antimicrobial resistance of Escherichia coli from animals: relationship to veterinary and management uses of antimicrobial agents. Appl Microbiol. 1971 Oct;22(4):700–705. doi: 10.1128/am.22.4.700-705.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schroeder S. A., Terry P. M., Bennett J. V. Antibiotic resistance and transfer factor in Salmonella, United States 1967. JAMA. 1968 Sep 23;205(13):903–906. [PubMed] [Google Scholar]
- Smith H. W. Effect of antibiotics on bacterial ecology in animals. Am J Clin Nutr. 1970 Nov;23(11):1472–1479. doi: 10.1093/ajcn/23.11.1472. [DOI] [PubMed] [Google Scholar]
- Sokol A., Koppel Z., Mikula L. Dynamics of incidence of antibiotic-(chemotherapeutic-) resistant E. coli in pigs and types of polyresistance of the isolated strains depending on addition of aureovit12 C20 to food. J Hyg Epidemiol Microbiol Immunol. 1969;13(3):347–357. [PubMed] [Google Scholar]
- Watanabe T. Infectious drug resistance in bacteria. Curr Top Microbiol Immunol. 1971;56:43–98. doi: 10.1007/978-3-642-65241-7_3. [DOI] [PubMed] [Google Scholar]