Abstract
The penetration of tobramycin sulfate (nebramycin factor 6) into normal lower respiratory tract secretions was studied in a dog model. After a 1.7 mg/kg intravenous dose of tobramycin, the antibiotic was detected promptly in bronchial secretions, but the peak bronchial secretion concentration was not usually reached until 2 h after injection (mean level 1.15 μg/ml). The maximum tobramycin concentration in bronchial fluids was equal to the mean inhibitory concentrations that have been reported for about 80% of Pseudomonas isolates.
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Selected References
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- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bodey G. P., Stewart D. In vitro studies of tobramycin. Antimicrob Agents Chemother. 1972 Sep;2(3):109–113. doi: 10.1128/aac.2.3.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Del Bene V. E., Farrar W. E., Jr Tobramycin: in vitro activity and comparison with kanamycin and gentamicin. Antimicrob Agents Chemother. 1972 Apr;1(4):340–342. doi: 10.1128/aac.1.4.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koch K. F., Rhoades J. A. Structure of nebramycin factor 6, a new aminoglycosidic antibiotic. Antimicrob Agents Chemother (Bethesda) 1970;10:309–313. [PubMed] [Google Scholar]
- Levison M. E., Knight R., Kaye D. In vitro evaluation of tobramycin, a new aminoglycoside antibiotic. Antimicrob Agents Chemother. 1972 May;1(5):381–384. doi: 10.1128/aac.1.5.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pennington J. E., Reynolds H. Y. Concentrations of gentamicin and carbenicillin in bronchial secretions. J Infect Dis. 1973 Jul;128(1):63–68. doi: 10.1093/infdis/128.1.63. [DOI] [PubMed] [Google Scholar]
- Tillotson J. R., Lerner A. M. Characteristics of nonbacteremic Pseudomonas pneumonia. Ann Intern Med. 1968 Feb;68(2):295–307. doi: 10.7326/0003-4819-68-2-295. [DOI] [PubMed] [Google Scholar]
- Traub W. H., Raymond E. A. Evaluation of the in vitro activity of tobramycin as compared with that of gentamicin sulfate. Appl Microbiol. 1972 Jan;23(1):4–7. doi: 10.1128/am.23.1.4-7.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waitz J. A., Moss E. L., Jr, Drube C. G., Weinstein M. J. Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin. Antimicrob Agents Chemother. 1972 Dec;2(6):431–437. doi: 10.1128/aac.2.6.431. [DOI] [PMC free article] [PubMed] [Google Scholar]