Abstract
Growth of Mycoplasma pneumoniae was completely prevented by 0.06 μg of actinomycin D/ml, and 0.00375 μg/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 μg/ml) of the antibiotic primarily inhibited ribonucleic acid synthesis and high concentrations (20 μg/ml) inhibited both ribonucleic and deoxyribonucleic acid synthesis.
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Selected References
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