Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Aug;6(2):183–190. doi: 10.1128/aac.6.2.183

Characteristics and Expression of Tetracycline Resistance in Gram-Negative Bacteria Carrying the Pseudomonas R Factor RP1

Patricia L Shipley 1, Ronald H Olsen 1
PMCID: PMC444625  PMID: 15828190

Abstract

The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RP1-containing organisms. The tetracycline resistance mechanism is inactivated at low temperatures. The effect of metabolic inhibitors on tetracycline accumulation by susceptible organisms under various conditions indicates a possible nonspecific effect of cellular energy metabolism on tetracycline uptake.

Full text

PDF
183

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIMA K., IZAKI K. ACCUMULATION OF OXYTETRACYCLINE RELEVANT TO ITS BACTERICIDAL ACTION IN THE CELLS OF ESCHERICHIA COLI. Nature. 1963 Oct 12;200:192–193. doi: 10.1038/200192a0. [DOI] [PubMed] [Google Scholar]
  2. Anderson E. S. The ecology of transferable drug resistance in the enterobacteria. Annu Rev Microbiol. 1968;22:131–180. doi: 10.1146/annurev.mi.22.100168.001023. [DOI] [PubMed] [Google Scholar]
  3. Brzezinska M., Davies J. Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors. Antimicrob Agents Chemother. 1973 Feb;3(2):266–269. doi: 10.1128/aac.3.2.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies J. E., Rownd R. Transmissible multiple drug resistance in Enterobacteriaceae. Science. 1972 May 19;176(4036):758–768. doi: 10.1126/science.176.4036.758. [DOI] [PubMed] [Google Scholar]
  5. De Zeeuw J. R. Accumulation of tetracyclines by Escherichia coli. J Bacteriol. 1968 Feb;95(2):498–506. doi: 10.1128/jb.95.2.498-506.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Engelman D. M. X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawii. J Mol Biol. 1970 Jan 14;47(1):115–117. doi: 10.1016/0022-2836(70)90407-9. [DOI] [PubMed] [Google Scholar]
  7. Franklin T. J., Higginson B. Active accumulation of tetracycline by Escherichia coli. Biochem J. 1970 Jan;116(2):287–297. doi: 10.1042/bj1160287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Franklin T. J. Resistance of Escherichia coli to tetracyclines. Changes in permeability to tetracyclines in Escherichia coli bearing transferable resistance factors. Biochem J. 1967 Oct;105(1):371–378. doi: 10.1042/bj1050371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Franklin T. J., Rownd R. R-factor-mediated resistance to tetracycline in Proteus mirabilis. J Bacteriol. 1973 Jul;115(1):235–242. doi: 10.1128/jb.115.1.235-242.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fullbrook P. D., Elson S. W., Slocombe B. R-factor mediated beta-lactamase in Pseudomonas aeruginosa. Nature. 1970 Jun 13;226(5250):1054–1056. doi: 10.1038/2261054a0. [DOI] [PubMed] [Google Scholar]
  11. Fullbrook P. D., Elson S. W., Slocombe B. R-factor mediated beta-lactamase in Pseudomonas aeruginosa. Nature. 1970 Jun 13;226(5250):1054–1056. doi: 10.1038/2261054a0. [DOI] [PubMed] [Google Scholar]
  12. Grinsted J., Saunders J. R., Ingram L. C., Sykes R. B., Richmond M. H. Properties of a R factor which originated in Pseudomonas aeruginosa 1822. J Bacteriol. 1972 May;110(2):529–537. doi: 10.1128/jb.110.2.529-537.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Izaki K., Kiuchi K., Arima K. Specificity and mechanism of tetracycline resistance in a multiple drug resistant strain of Escherichia coli. J Bacteriol. 1966 Feb;91(2):628–633. doi: 10.1128/jb.91.2.628-633.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levy S. B., McMurry L. Detection of an inducible membrane protein associated with R-factor-mediated tetracycline resistance. Biochem Biophys Res Commun. 1974 Feb 27;56(4):1060–1068. doi: 10.1016/s0006-291x(74)80296-2. [DOI] [PubMed] [Google Scholar]
  15. Olsen R. H., Shipley P. Host range and properties of the Pseudomonas aeruginosa R factor R1822. J Bacteriol. 1973 Feb;113(2):772–780. doi: 10.1128/jb.113.2.772-780.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Reynard A. M., Nellis L. F., Beck M. E. Uptake of 3H-Tetracycline by resistant and sensitive Escherichia coli. Appl Microbiol. 1971 Jan;21(1):71–75. doi: 10.1128/am.21.1.71-75.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Reynard A. M., Nellis L. F. Uptake of tetracycline by Escherichia coli: lack of binding of tetracycline to the uptake system. Biochem Biophys Res Commun. 1972 Sep 5;48(5):1129–1132. doi: 10.1016/0006-291x(72)90827-3. [DOI] [PubMed] [Google Scholar]
  18. Robertson J. M., Reeve E. C. Analysis of the resistance mediated by several R-factors to tetracycline and minocycline. Genet Res. 1972 Oct;20(2):239–252. doi: 10.1017/s0016672300013744. [DOI] [PubMed] [Google Scholar]
  19. Smith J. T. R-factor gene expression gram-negative bacteria. J Gen Microbiol. 1969 Jan;55(1):109–120. doi: 10.1099/00221287-55-1-109. [DOI] [PubMed] [Google Scholar]
  20. Sompolinsky D., Krawitz T., Zaidenzaig Y., Abramova N. Inducible resistance to tetracycline in Staphylococcus aureus. J Gen Microbiol. 1970 Aug;62(3):341–349. doi: 10.1099/00221287-62-3-341. [DOI] [PubMed] [Google Scholar]
  21. Tseng J. T., Bryan L. E. Mechanisms of R factor R931 and chromosomal tetracycline resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1973 May;3(5):638–641. doi: 10.1128/aac.3.5.638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. VOGEL H. J., BONNER D. M. Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956 Jan;218(1):97–106. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES